High-Speed Optical Imaging for Medical Diagnosis and Therapy

描述(申请人提供)：本提案的目标是获得一种用于生物医学研究的高速数字成像系统。该系统能够以每秒2亿帧的速率记录多达16幅图像，即5纳秒曝光和背靠背成帧。一种名为条纹模式的特殊模式可用于以高达每秒20亿行的速度记录单条图像线。放射科和生物医学工程系的8名研究人员组成了一个小组。该小组的成员由R01和R21/33型NIH赠款单独资助。所有项目都在研究微米大小的气泡和液滴动力学的一般领域，无论是针对单个粒子还是针对云，以及组织对超声波或聚焦激光曝光的反应。一些项目是直接相关的，所有这些项目最终都将有助于更好地了解超声波或激光治疗的机制，或者实际上使治疗成为可能。该摄像系统将立即用于监测声学和光学领域中粒子的形成，以及它们在声学和光学作用力下的变形和运动(也用于组织)。此外，颗粒动力学造成的生物损害将被测量和评估，以用于治疗或确定诊断程序的安全指南/法规。成立了一个委员会，并制定了指导方针，以便在该小组成员之间使用和分享摄像系统，并使新用户能够接触该设备并对其进行培训。这是为了确保系统的最佳利用和对所列项目的最大贡献，并不断确定将从这一装置中受益的其他国家卫生研究院项目。拟议的摄像机系统可以提供非常短暂的事件的图像(每秒2亿张图像)。使用超声波或激光的医学检查与人体组织相互作用的时间尺度也很小。这款相机能够记录这些检查的图像，帮助我们更好地了解如何提高诊断和治疗水平。

DESCRIPTION (provided by applicant): The objective of this proposal is to acquire a high-speed digital imaging system for use in biomedical research. This system is capable of recording up to 16 images at a rate of up to 200 million frames per second, i.e. 5 nano seconds exposure and back to back framing. A special mode, called streak mode, can be used to record single image lines with a speed of up to 2 billion lines per second. A group of 8 investigators in the Departments of Radiology and Biomedical Engineering was formed. The members of this group are individually funded by R01 and R21/33 type NIH grants. All projects are investigating the general field of micrometer sized bubbles and droplets dynamics, either for individual particles or for clouds, as well as tissue response to ultrasound or focused laser exposure. Some projects are immediately interrelated and all of them will ultimately help to either provide a better understanding for the mechanisms of ultrasound or laser therapy or actually enable therapy. Immediate use of the camera system will be for monitoring the formation of particles in acoustical and optical fields as well as their deformation and motion (also for tissue) due to acoustical and optical forces. Moreover, biological damage resulting from particle dynamics will be measured and evaluated for therapeutic use or to determine safety guidelines/regulations for diagnostic procedures. A committee was formed and guidelines were established by which the camera system can be used and shared among the members of this group and by which new users can gain access to and training for the device. This is to ensure best possible use of the system and maximum contribution for the listed projects and to continuously identify other NIH projects that will benefit from this device. The proposed video camera system can provide images of events that are very short lived (200 million images per second). Medical examinations using ultrasound or laser interact with the human tissue on a time scale that is also very small. This camera is able to record images of these examinations and help us to better understand how to improve diagnosis and treatment.