BIOMIMETIC HETEROGENEOUS CATALYSIS FOR ENANTIOSELECTIVE OXIDATIONS

拟议的研究将允许人员在谢菲尔德和约克之间自由流动，为期两年，尽管它打算将其扩展为长期的重点合作。高附加值有机分子对映选择性氧化的绿色可持续催化剂和工艺是研究的总体目标。该项目的最终目标是使用正相水或超临界二氧化碳作为溶剂合成关键的有机环氧化物和二氢氧化物。研究的初始阶段将确定用于小型和大规模合成多孔催化剂载体和活性金属配合物的候选系统。这将涉及固体催化剂合成和表征的关键技能的转移，以及中试工厂规模的材料制备。这将导致微反应器系统的设计、建造和测试，用于连续流处理，包括使用LabView软件实施控制程序。此外，我们将使用负载催化剂的表面分析来探索反应机理和失活途径，以帮助下一代催化剂的开发。这项工作的最终成果是开发一种环境友好、清洁和可持续的工艺，采用包括水和超临界二氧化碳在内的良性溶剂系统，用于生产商业上重要的化学产品。这些技术在商业意义上的实施将通过我们与Astra Zeneca Charnwood工艺研究和开发的合作进行评估。在研究计划的同时，这一学科的跳跃将使我们能够在化学和化学工程的界面上开发新的教学资源。

The research proposed will allow free movement of personnel between Sheffield and York over an initial two-year period although it is intended to extend this into a long-term focussed collaboration. The general target is green and sustainable catalysts and processes for the enantioselective oxidation of organic molecules with high added value. The ultimate aim of this project will be to synthesise key organic epoxides and dihydroxides using either normal phase water or supercritical carbon dioxide as the solvent.The initial phase of the research will identify candidate systems for the small and large-scale synthesis of porous catalyst supports and active metal complexes. This will involve the transfer of key skills in solid catalyst synthesis and characterisation and the pilot plant scale preparation of materials This will lead on to the design, construction and testing of micro reactor systems for continuous flow processing, including the implementation of control procedures using LabView software. Furthermore, we will use surface analysis of the supported catalysts to probe reaction mechanisms and deactivation pathways in order to aid the development of next generation catalysts.The work culminates in the development of an environmentally friendly clean and sustainable process, employing benign solvent systems including water and supercritical carbon dioxide, for the production of commercially important chemical products. The implementation of these technologies in a commercial sense will be assessed through our association with Astra Zeneca Charnwood, Process Research and Development.In parallel to the research programme this discipline hop will allow us to develop new teaching resources at the interface between chemistry and chemical engineering.