Contingent Tolerance to Cocaine in Pigeons

描述（由申请人提供）：先前关于大鼠和猴子对可卡因对操作行为影响的耐受性的研究表明，耐受性取决于药物是在治疗前还是治疗后给药。最近发表的一项关于鸽子的实验，初步研究没有发现耐受性同样取决于药物的施用时间。拟议的研究将通过三个实验进一步研究行为因素和药理因素在鸽子对可卡因耐受性发展中的作用。实验1将研究在可卡因的作用下进食对可卡因耐受性发展的贡献。实验2将研究单纯药物暴露而不暴露于行为会话在行为会话期间对可卡因耐受性发展的影响。实验3将研究急性和慢性可卡因给药对可卡因药代动力学的影响。该研究计划将研究行为因素的作用，包括实验会话和饮食，以及对鸽子中可卡因行为影响的耐受性发展中的药理学因素。

DESCRIPTION (provided by applicant): Previous research on tolerance to effects of cocaine on operant behavior in rats and monkeys has revealed tolerance contingent on whether the drug is given pre or post session. A recently published experiment with pigeons, and the preliminary study did not find that tolerance was similarly contingent on when the drug was administered. The proposed research will further examine the role of behavioral factors and pharmacological factors in the development of tolerance to cocaine in pigeons through three experiments. Experiment 1 will examine the contributions of eating while under the effects of cocaine to the development of tolerance to cocaine during a preceding operant behavioral session. Experiment 2 will examine effects of mere drug exposure without exposure to a behavioral session in the development of tolerance to cocaine during a behavioral session. Experiment 3 will examine effects of acute and chronic cocaine administration on the pharmacokinetics of cocaine. This program of research will examine the role of behavioral factors, including the experimental session and eating, and pharmacological factors in the development of tolerance to behavioral effects of cocaine in pigeons.