Translational Research Training in Sleep Medicine

描述（由申请人提供）：这是T32 HL082610“睡眠医学转化研究培训”的修订申请。为了回应之前的审查，我们重组了项目主管，增加了经验丰富的生物统计学家导师，并解决了每个审稿人的其他意见。该计划的目标是培养下一代临床和基础研究人员在睡眠医学的转化方法。睡眠障碍在心肺、代谢和神经系统中产生广泛的发病率。尽管最近在睡眠和昼夜节律的基础科学方面取得了科学突破，但在睡眠医学转化科学方面接受过培训的临床导向的研究人员很少。制定一个成功的转化睡眠医学培训计划需要一个强有力的多学科合作的基础，以代表该领域科学观点的多样性。匹兹堡大学就有这样的合作。来自三个学院（医学、公共卫生、护理）和医学院六个部门（精神病学、肺部医学、肾脏医学、神经病学、行为医学、神经科学）的大量合作研究人员目前接受外部资助进行睡眠研究。此外，该大学在睡眠研究方面拥有出色的基础设施和学术资源，包括临床神经科学研究中心、睡眠和昼夜节律实验室、流行病学系的两个领域中心和一个专门研究睡眠障碍动物模型的基础研究实验室。培训计划的主要重点是博士后培训，其次是指导医学生的研究。该大学的师资和资源最初将每年培养两名博士后，到第三年将增加到四名。该计划主要面向从肺部医学、精神病学、神经病学和内科领域招募的医学博士科学家。培训计划的核心将是指导研究经验，该经验将是多学科性质的，重点是转化，以对睡眠生理学的透彻理解为基础，并以表现为基础的里程碑为基础。该计划将包括为期八周的动物和人类睡眠生理学“基础培训”课程，持续强调研究成果的展示和出版，个人指定的课程，以及职业发展奖的准备（k系列申请）。该项目将包括学员和教师导师的定期反馈和评估，并将由一个由系主任和其他T32项目主任组成的研究咨询小组以及一个外部咨询委员会监督。医学生的研究经历旨在激发对睡眠医学的兴趣，并在更广泛的意义上解决转化研究面临的关键“管道”问题。

DESCRIPTION (provided by applicant): This is a revised application of T32 HL082610, "Translational Research Training in Sleep Medicine." In response to the previous review, we have reorganized the Program directorship, added experienced biostatistician mentors, and addressed each of the reviewers' other comments. The goal of this Program is to train the future generation of clinical and basic researchers in a translational approach to Sleep Medicine. Sleep disturbances produce wide-ranging morbidities in cardiopulmonary, metabolic, and neurological systems. Despite recent scientific breakthroughs in the basic science of sleep and circadian rhythms, there are few clinically-oriented investigators trained in the translational science of Sleep Medicine. Developing a successful training program in translational Sleep Medicine requires a foundation of vigorous multidisciplinary collaborations to represent the diversity of scientific perspectives in the field. Such collaborations exist at the University of Pittsburgh. A critical mass of collaborating researchers from three schools (Medicine, Public Health, Nursing) and six Departments or Divisions within the School of Medicine (Psychiatry, Pulmonary Medicine, Renal Medicine, Neurology, Behavioral Medicine, Neuroscience) currently receive external funding for sleep research. In addition, the University has an outstanding infrastructure and academic resources in sleep research including the Clinical Neuroscience Research Center, the Sleep and Circadian Rhythms Laboratory, two field centers within the Department of Epidemiology, and a basic research laboratory specializing in animal models of sleep disorders. The Training Program's primary focus will be on post-doctoral training, with a secondary focus on mentored medical student research. The faculty and resources of the University will initially train two postdoctoral fellows per year, building to four trainees by the third year. The Program is intended primarily for M.D. scientists recruited from the fields of Pulmonary Medicine, Psychiatry, Neurology, and Internal Medicine. The core of the Training Program will be a mentored research experience that will be multidisciplinary in nature, translational in focus, grounded in a thorough understanding of sleep physiology, and structured by performance-based milestones. The Program will feature initial immersion in an eight week "basic training" course in animal and human sleep physiology, ongoing emphasis on presentation and publication of research findings, individually-prescribed coursework, and preparation of a career development award (K-series applications). The Program will include scheduled feedback and evaluation of both trainees and faculty mentors, and will be overseen by a Research Advisory Group consisting of Department Chairs and other T32 Program Directors, as well as an External Advisory Board. The medical student research experiences are designed to stimulate interest in Sleep Medicine specifically, and to address the critical "pipeline" issue facing translational research in a more general sense.