Early Detection Research Network (EDRN) Cncr Rsrch Informatics Platform

Y1-CN-5004-05 JPL美国国家癌症研究所癌症预防部门的癌症生物标志物研究小组已经与NASA的Jet谈判达成了一项跨部门协议，以设计、建造、实施和维护一个信息学基础设施，以支持早期检测研究网络(EDRN)的癌症生物标志物的科学发现、开发和验证。 生物医学研究中的推进实验室科学发现越来越依赖于从各种资源中挖掘和关联不同的数据集。NCI的早期检测研究网络(EDRN)邀请了30个研究中心的多学科科学家参与癌症生物标记物的合作研究。EDRN的分布式性质代表着建立生物信息学基础设施以捕获和分发网络中的科学和辅助数据的现代挑战。喷气推进实验室(JPL)是EDRN信息学工作组的主要参与者之一，一直在领导设计和实施这种生物医学数据管理和交付基础设施的持续努力。我们的第一个应用程序侧重于提供一个通用的信息学框架，用于访问位于参与EDRN站点的不同种类的标本存储库。这项任务计划通过提供一个端到端的癌症研究平台来继续发展这一基础设施。EDRN目录和档案服务(ECAS)将是一个关键组成部分，它支持捕获和分发在验证研究期间获得的已发表科学数据。此外，我们将继续将EDRN资源网络交换发展为一个共享标本信息的虚拟系统。 该基础设施将满足EDRN信息学目标，包括： I)描述EDRN科学数据的通用信息模型； 2)远程获取从多个EDRN参与点发布的科学数据； 三)跨生物医学应用程序共享数据的软件接口； 4)向科学界安全地传输和分发数据； V)搜索和下载EDRN科学产品的网络界面。

Y1-CN-5004-05 JPL The National Cancer Institute, Division of Cancer Prevention's Cancer Biomarkers Research Group has negotiated an Interagency Agreement with NASA's Jet to design, build, implement and maintain an Informatics Infrastructure to support scientific discovery, development and validation of cancer biomarkers for the Early Detection Research Network (EDRN). Propulsion Laboratory Scientific discovery in biomedical research increasingly depends on mining and correlating diverse data sets from various resources. The Early Detection Research Network (EDRN) of NCI engages scientists of multiple disciplines across 30 research centers in a collaborative research of cancer biomarker. The distributed nature of the EDRN represents a modern challenge for building a bioinformatics infrastructure to capture and distribute science and ancillary data within the network. The Jet Propulsion Laboratory (JPL), one of the key players of the EDRN Informatics Working Group, has been leading the ongoing effort in architecting and implementing such a biomedical data management and delivery infrastructure. Our first application focused on providing a common informatics framework for accessing heterogeneous specimen repositories located at participating EDRN sites. This task plan continues to evolve that infrastructure by moving towards delivery of an end-to-end cancer research platform. One key component will be the EDRN Catalog and Archive Service (eCAS), which supports the capture and distribution of the published science data acquired during a validation study. In addition, we will continue to evolve the EDRN Resource Network Exchange as a virtual system for sharing specimen information. The infrastructure will satisfy EDRN informatics goals including: i) a common information model for describing EDRN science data; ii) acquisition of science data published from multiple EDRN participating sites remotely; iii) software interfaces for sharing of data across biomedical applications; iv) secure transfer and distribution of data to the science community; v) a web-based interface to search and download EDRN science products.