Translational Neuroscience Research in Alcoholism

描述（由申请人提供）：在将基础科学研究中获得的知识应用于与酒精中毒相关的临床神经科学研究模型方面存在持续的差距。新一代的精神药理学、神经影像学和分子遗传学研究植根于分子神经科学，具有广泛的临床意义，这些研究带来了弥合基础和临床研究之间差距的潜力。尽管现有科学的质量很高，但在实际弥合这一差距方面的进展还取决于是否有受过适当培训的年轻科学家。该培训计划的目的是通过为总共3名对酗酒领域的转化研究职业感兴趣的医生或博士提供博士后培训来满足这一需求。拟议的培训计划是一个为期两年的计划，在精神病学系，耶鲁大学医学院，并将提供博士后学员的机会，投入几乎全职的努力，在他们的职业生涯的初始阶段，以发展所需的技能和经验，成为独立的研究人员在酒精中毒的转化研究领域。在该计划中，有四个核心计划，临床核心，神经影像核心，遗传学核心和基础科学核心。该计划的教师隶属于两个中心赠款（NIAAA资助的酒精中毒转化神经科学中心和VA资助的VA酒精研究中心），这两个中心都是多学科的，使该小组能够进行研究，从临床前项目（“工作台”）到临床研究（“床边”和“社区”）的两个方向快速移动。申请人将是医学博士或博士博士后候选人，他们接受过精神病学、内科学、临床心理学或神经科学等专业的培训。候选人将由录取委员会根据他们在酗酒转化研究领域的卓越潜力进行选择。三名申请人将被选中每年的核心组件：两个临床为导向的核心程序（临床或神经影像学）和一个基础科学或遗传学的核心。该计划包括（1）个性化的研究preceptorship，（2）成功完成一个预防性研究项目，（3）核心课程，其中包括药物滥用临床研究和治疗，生物统计学和研究设计研讨会，科学研究和赠款写作技能的负责任的行为和（4）在部门感兴趣的研讨会个性化参与，医学院和大学，（5）临床培训;（6）教学培训。培训设施包括耶鲁医学院附属的主要机构精神病学系。在培训结束时，申请人将非常适合在酗酒领域的翻译研究的独立职业。

DESCRIPTION (provided by applicant): There is a persistent gap in the application of knowledge gained from basic science studies to clinical neuroscience research models related to alcoholism. A new generation of psychopharmacology, neuroimaging, and molecular genetic studies rooted in molecular neuroscience has broad clinical implications and these studies bring the potential to bridge the gap between basic and clinical research. Despite the quality of the available science, progress in actually bridging this gap depends also upon the availability of appropriately trained young scientists. The purpose of this training program is to meet this need by providing post-doctoral training for a total of 3 physicians or PhDs interested in careers in translational research in the field of alcoholism. The proposed training program is a two-year program in the Department of Psychiatry, Yale University School of Medicine, and will afford post-doctoral trainees the opportunity to devote virtually full-time effort during the initial phase of their careers to developing the skills and experience needed to become independent researchers in the field of translational research in alcoholism. Within this program, there are four Core Programs, the Clinical Core, the Neuroimaging Core, the Genetics Core and the Basic Science Core. The program faculty are affiliated with two center grants (the NIAAA-funded Center for the Translational Neuroscience of Alcoholism and the VA-funded VA Alcohol Research Center), both of which are multi-disciplinary and enable the group to conduct research that moves rapidly and in both directions from preclinical projects ("bench") to clinical studies ("bedside" and "community"). Applicants will be MD's or PhD post-doctoral candidates trained in specialties that include psychiatry, internal medicine, clinical psychology or neuroscience. Candidates will be selected by an admission committee based on their potential for excellence in the field of translational research in alcoholism. Three applicants will be selected annually for the Core Components: two for the clinically-oriented core programs (Clinical or Neuroimaging) and one for the Basic Science or Genetics core. The program includes (1) individualized research preceptorship, (2) successful completion of a translational-research project, (3) a core curriculum, which include seminars on substance abuse clinical research and treatment, biostatistics and research design, the responsible conduct of scientific research and grant writing skills and (4) individualized participation in seminars of interest in the Department, Medical School and University, (5) clinical training and (6) training for teaching. The training facilities include the major institutions affiliated with Yale School of Medicine, Department of Psychiatry. At the conclusion of training, applicants will be well suited for independent careers in translational research in the field of alcoholism.