Pathogenesis of Infectious Diseases Training Program

描述(由申请人提供)：该计划的目标是培养生物医学研究方面的内科科学家，重点是传染病的发病机制。重点将放在具有世界重要性的疾病上，包括结核病、疟疾、利什曼病、丙型肝炎和艾滋病。 培训计划将利用康奈尔大学威尔医学院(W.Johnson、E.Cesarman、K.Deitsch、S.Ehrt、L.Golighly、J.Ho、C.Nathan、D.Schnappinger、T.Templeton)、洛克菲勒大学(D.Ho、C.莱斯、R.Steinman)和艾伦·戴蒙德艾滋病研究中心(D.Ho)的资源。该项目的高级教员是由科学家资助的，致力于研究和培训。六名新的潜在导师被包括在内--都得到了独立的NIH研究支持。培训教师在通过NIH Fogarty项目成功合作研究和培训国际生物医学科学家方面有着悠久的历史，并已将这些经验应用于美国内科科学家的培训。 在目前的供资期间(1999-2003年)，任命了10名受训人员--其中4人获得了NIH“K”奖，2人提交了研究补助金。这些奖项的主题领域是KSHV-HHV8、艾滋病毒发病机制、艾滋病毒-结核病合并感染、艾滋病毒疫苗开发、利什曼病发病机制和结核分枝杆菌-无相互作用。在其中的每一个中 获奖后，主要的T32导师继续担任K奖项导师。两名前受训人员正在进行艾滋病毒疫苗和生物恐怖主义的研究和培训。最近的两名受训人员正在确定他们的研究项目(艾滋病毒-结核病相互作用和艾滋病毒-丙型肝炎合并感染)。有3名少数族裔受训人员(2名非洲裔美国人，1名西班牙裔)和3名女性受训人员。 该计划将继续招聘已完成临床培训(医学、儿科、病理学)并正在寻求学术研究职业的医生。训练有素的教职员工都认为，内科医生兼科学家确实是濒危物种。这笔培训补助金将为年轻医生提供从临床培训过渡到实验室的机会。研究性培训为期2-3年，每年5名研究员。学员将有机会与海地(D.Fitzgerald，J.Pape)和巴西(E.Carvalho和A.Ko)的杰出导师合作，如果这与美国的实验室研究有关的话。海地和巴西的研究重点是艾滋病毒自然病史和传播研究、机会性感染(利什曼病、结核病)、流行病学、免疫病理学和干预措施(行为、药物、疫苗)。

DESCRIPTION (provided by applicant): The objective of this program is to train physician-scientists in biomedical research, with an emphasis on the pathogenesis of infectious diseases. The focus will be on diseases of worldwide importance, including tuberculosis, malaria, leishmaniasis, hepatitis C, and AIDS. The training program will utilize the resources of Weill Medical College of Cornell University (W. Johnson, E. Cesarman, K. Deitsch, S. Ehrt, L. Golightly, J. Ho, C. Nathan, D. Schnappinger, T. Templeton), the Rockefeller University (D. Ho, C. Rice, R. Steinman), and the Aaron Diamond AIDS Research Center (D. Ho). The program's senior faculty are funded scientists, committed to research and training. Six new potential mentors have been included - all with independent NIH research support. The training faculty has a long history of successful collaboration in research and training of international biomedical scientists through NIH Fogarty programs and have applied that experience to the training of US physician-scientists. During the current funding period (1999-2003), 10 trainees have been appointed--four have received and two have submitted NIH "K" awards or research supplements. The subject areas for these awards are KSHV-HHV8, HIV pathogenesis, HIV-TB coinfection, HIV vaccine development, leishmania pathogenesis and M. tuberculosis-NO interaction. In each of these awards, the primary T32 mentor continues as the K award mentor. Two former trainees are conducting research and training on HIV vaccines and bioterrorism. The two most recent trainees are in the process of defining their research projects (HIV-TB interaction and HIVhepatitis C coinfection). There have been three minority trainees (2 African-American, 1 Hispanic) and three female trainees. The program will continue to recruit physicians who have completed their clinical training (medicine, pediatrics, pathology) and are seeking academic investigative careers. The training faculty share the view that the physician-scientist is truly an endangered species. This training grant will provide young physicians with an opportunity to make the transition from their clinical training to the laboratory. The research training will be for 2-3 years with five fellows each year. Trainees will have the opportunity to work with outstanding mentors in Haiti (D. Fitzgerald, J. Pape) and in Brazil (E. Carvalho and A. Ko), if it is relevant to the US laboratory research. The research in Haiti and Brazil is focused on HIV natural history and transmission studies, opportunistic infections (leishmaniasis, tuberculosis), epidemiology, immunopathology, and interventions (behavioral, drug, vaccine).