PATHOGENESIS OF INFECTIOUS DISEASES TRAINING PROGRAM

该计划的目标是培养基础生物医学研究方面的内科科学家，重点是传染病的发病机制。重点将放在具有世界重要性的疾病上，特别是利什曼病和艾滋病毒感染。该培训计划将利用康奈尔大学医学院（W. Johnson， E. Cesarman， J. Ho， C. Nathan）、洛克菲勒大学（D. Ho， R. Steinman）和Aaron Diamond艾滋病研究中心（D. Ho）的资源。该项目的教师都是医生和受资助的科学家，致力于研究艾滋病毒及其主要的机会性感染。培训教员在通过NIH福格蒂项目进行国际生物医学科学家的研究和培训方面有着悠久的成功合作历史，现在将把这一经验应用于美国内科科学家的培训。该项目将招募完成临床培训（医学、儿科、病理学）并寻求学术研究事业的美国医生。培训教员们都认为，医生兼科学家确实是一种濒危物种。这项培训补助金将为年轻医生提供从临床培训过渡到实验室的机会。研究培训为期2-3年，每年培养4名研究员。如果与美国实验室研究相关，受训者将有机会与海地（Pape）和巴西（Carvalho和Lapa e Silva）的杰出导师一起工作。海地和巴西的研究重点是艾滋病毒自然史和传播研究、机会性感染（利什曼病、结核病、流行病学、免疫病理学）和干预措施（行为、药物、疫苗）。

The objective of this program is to train physician-scientists in basic biomedical research, with an emphasis on the pathogenesis of infectious diseases. The focus will be on diseases of worldwide importance, in particular, leishmaniasis and HIV infection. The training program will utilize the resources of Cornell University Medical College (W. Johnson, E. Cesarman, J. Ho, C. Nathan), the Rockefeller University (D. Ho, R. Steinman), and the Aaron Diamond AIDS Research Center (D. Ho). The program faculty are all physicians and funded scientists, committed to research on HIV and its major opportunistic infections. The training faculty has a long history of successful collaboration in research and training of international biomedical scientists through NIH Fogarty programs and will now apply that experience to the training of US physician-scientists. The program will recruit US physicians who have completed their clinical training (medicine, pediatrics, pathology) and are seeking academic investigative careers. The training faculty share the view that the physician-scientist is truly an endangered species. This training grant will provide young physicians with an opportunity to make the transition from their clinical training to the laboratory. The research training will be for 2-3 years with four fellows in each year. Trainees will have the opportunity to work with outstanding mentors in Haiti (Pape) and in Brazil (Carvalho and Lapa e Silva), if it is relevant to the US laboratory research. The research in Haiti and Brazil is focused on HIV natural history and transmission studies, opportunistic infections (leishmaniasis, tuberculosis, epidemiology, immunopathology, and interventions (behavioral, drug, vaccine).