Does Moderate Intensity Exercise Help Prevent Smoking Relapse Among Women?

描述（由申请人提供）：烟草使用仍然是女性癌症的主要、可预防的原因;然而，大约21%的女性继续吸烟。情绪相关的戒断症状和对戒烟后体重增加的担忧是初次戒烟后复发的重要预测因素，尤其是在女性中。中等强度的运动是标准戒烟治疗的一种安全且低成本的辅助手段，可以通过改善戒烟期间的情绪和减轻体重问题来帮助预防复发。以前的大规模干预试验没有发现中等强度运动的显著效果，但是坚持这些运动计划的效果很差，因此运动的效果不能与坚持计划的效果分开。相反，对照实验室研究表明，急性中等强度的运动可以减少烟瘾和戒断症状，但这些效果尚未经过长期或长期运动计划的测试。这项拟议的研究将试点研究方法，将长期中等强度运动计划对健康成年女性吸烟者戒烟的影响隔离开来。具体而言，我们计划在60名健康女性中比较标准戒烟治疗（包括一次性简短咨询和提供尼古丁贴片加上8周中等强度运动计划）与相同标准戒烟治疗加上等效接触控制的效果。一些技术将被用来提高治疗方案的依从性，从而更有效地隔离运动的影响。其中包括：（1）随机化前两周的导入期;（2）在参与者随机化前使用行为契约;（3）现场进行所有锻炼。将通过一氧化碳和唾液可替宁验证戒烟结局（持续戒烟和点戒烟率）。身体活动将通过监督会议的出席率进行评估。

DESCRIPTION (provided by applicant): Tobacco use continues to be the leading, preventable cause of cancer among women; however, approximately 21 % of women continue to smoke cigarettes. Mood-related withdrawal symptoms and concerns about weight-gain following cessation are significant predictors of relapse following initial cessation, especially among women. Moderate intensity exercise is a safe and low-cost adjunct to standard smoking cessation treatments that may help prevent relapse by improving mood and attenuating weight concerns during smoking cessation. Previous large-scale intervention trials have not found a significant effect for moderate intensity exercise, but adherence to these exercise programs has been poor, and therefore the effects of exercise cannot be isolated from the effects of program adherence. Conversely, controlled laboratory studies have shown that acute moderate intensity exercise can reduce cigarette cravings and withdrawal symptoms, but these effects have not been tested over the long term or with a prolonged exercise program. The proposed study will pilot research methods that will isolate the effects of a prolonged moderate intensity exercise program on smoking cessation among healthy adult female smokers. Specifically, we plan to compare the effects of a standard smoking cessation treatment, including one-time brief counseling and provision of nicotine patch plus an 8-week moderate intensity exercise program versus the same standard smoking cessation treatment plus equivalent contact control among 60 healthy women. A number of techniques will be used to increase compliance with the treatment program, thus more effectively isolating the effects of exercise. These include: (1) a two-week run-in period prior to randomization; (2) use of behavioral contracting prior to participant randomization; and (3) performance of all exercise on-site. Smoking cessation outcomes (continuous abstinence and point prevalence abstinence) will be verified by carbon monoxide and saliva cotinine. Physical activity will be evaluated by attendance at the supervised sessions.