Core Center for Quantitative Neuroscience with Magnetic Resonance (QNMR)

描述（由申请人提供）： 磁共振（MR）技术在生命科学研究中的应用正在迅速增长。耶鲁大学磁共振研究中心（MRRC）培养的最先进的异源磁共振波谱（MRS）和多模态磁共振成像（MRI）方法已经将体内动物研究转移到实验神经科学的核心角色，解决了对大脑功能具有深远影响的基本问题。自20世纪80年代初耶鲁MRRC成立以来，用于体内研究的水平孔磁体数量在2004年翻了三倍。目前用于体内研究的磁体数量-动物和人类各三个-需要与许多学科越来越多的研究人员相匹配-其中大多数由NINDS支持。耶鲁MRRC的优势一直是，现在仍然是，啮齿动物和人类研究之间的动态互动。此外，在啮齿动物和人类中异源MRS和多模态MRI方法之间的积极相互作用已经迅速发展。由于MR技术需要坚定不移的基础设施支持，以成功应用最先进的技术，耶鲁MRRC的长期稳定性取决于持续的支持。耶鲁大学的“定量神经科学与磁共振（QNMR）”项目将支持耶鲁大学NINDS资助的研究人员使用的共享资源和设施，从而产生比独立工作更高的生产力。QNMR将由三个研究核心组成-每个核心致力于提高基于多模态MRI，异频MRS，神经生理学的正在进行的研究的有效性-和一个服务核心-旨在使用高性能工作站集群进行快速数据分析，访问，共享和备份。我们期望QNMR将为耶鲁大学利用MR技术的神经科学家提供一个更具合作性和互动性的研究环境，并将在医学，生理学和神经科学方面培养新的跨学科方法。

DESCRIPTION (provided by applicant): Applications of magnetic resonance (MR) techniques to research in the life sciences are growing rapidly. State-of-the-art heteronuclear MR spectroscopy (MRS) and multi-modal MR imaging (MRI) methodologies cultivated at the Magnetic Resonance Research Center (MRRC) at Yale have moved in vivo animal research into central roles in experimental neuroscience, addressing fundamental issues with far reaching implications for brain function. Since the formation of the Yale MRRC in the early in 1980s, the number of horizontal-bore magnets for in vivo studies has multiplied three-fold in 2004. The present number of magnets for in vivo studies - three each for animals and humans - were needed to match the growing number of investigators across many disciplines - a majority of whom are supported by NINDS. The strength of the Yale MRRC has been, and still is, the dynamic interaction between rodent and human research. Active interplay between heteronuclear MRS and multi-modal MRI methods in rodents and humans have furthermore rapidly progressed. Because MR technology requires unwavering infrastructural support for state-of-the-art exploits to be successfully applied, long-term stability of Yale MRRC is contingent on sustained support. A program in "Quantitative Neuroscience with Magnetic Resonance (QNMR)" at Yale will support shared resources and facilities used by NINDS-funded investigators at Yale, and thereby generate greater productivity than would be possible via independent efforts. QNMR will consist of three research Cores - each dedicated to improving effectiveness of ongoing research based upon multi- modal MRI, heteronuclear MRS, neurophysiology - and one service Core - designed for rapid data analysis, access, sharing, and backup using high-performance cluster of workstations. We expect that QNMR will promote a more cooperative and interactive research environment for neuroscientists who are utilizing MR technology at Yale, and will nurture new cross-disciplinary approaches in medicine, physiology, and neuroscience.