CORE--Principal Research

Principal Research旨在增加循证干预措施的数量和可用性 适用于患有抑郁症及其并发症的高危老年人， 在专业精神卫生部门和初级保健部门看到的疾病， 康复中心，以及疗养院和其他长期护理机构。 干预研究将针对以下主题：（1）预防老年人抑郁和自杀 改善、预防或延迟老年抑郁症患者的认知和功能障碍; (2)改善对晚年难以治疗的情绪障碍的治疗（例如，躁郁症，精神抑郁症， 和对一线治疗仅部分响应的单极重性抑郁症）;和（3）识别和去除 在社区临床环境中有效治疗抑郁症的障碍。贯穿这些主题的是中心 目标（4）利用基础设施支持，增加心理健康和老龄化方面的研究培训机会 以及基于社区的参与性研究。 这些主题反映了我们从功效到有效性研究，到服务，传播和 实践研究，如NIMH理事会报告中所规定的，Bridqin. q科学与服务。为此目的 主要研究核心和研究网络发展核心之间的双向联系是 至关重要的科学意义。

Principal Research seeks to increase the number and availability of evidence-based interventions applicable to elderly persons at high risk for depression and its complications, to those with difficult to treat mood disorders seen within the specialty mental health sector, and to those seen in the primary care sector, in rehabilitation centers, and in nursing home and other long term care settings. Intervention studies will address the following themes: (1) preventing depression and suicide in elderly persons at high risk; and improving, preventing, or delaying cognitive and functional impairments in elderly with depression; (2) improving treatment for difficult to treat mood disorders in later life (e.g., bipolar disorders, psychotic depression, and unipolar major depression responding only partially to first line treatment); and (3) identifying and removing barriers to effective depression treatment in community clinical settings. Cutting across these themes is the Center objective (4) of using infrastructure support to enhance research-training opportunities in mental health and aging and in community-based participatory research. These themes capture our movement from efficacy to effectiveness research, to services, dissemination, and practice research, as mandated in the NIMH Council report, Bridqin.q Science and Service. To this end the bidirectional linkages between the Principal Research Core and the Research Network Development Core are of critical scientific importance.