ACS Symposium, Frontiers in Chemical Toxicology

描述（由申请人提供） 该资助申请要求为一系列题为“化学毒理学前沿”的专题讨论会提供部分资助。这些专题讨论会是美国化学学会化学毒理学分部于2008年8月17日至21日在宾夕法尼亚州费城举行的第236届全国会议和学会博览会上提出的计划的一部分。 这些专题讨论会将为化学毒理学关键领域的新兴研究提供论坛，包括1）与修复相关的DNA损伤的结构生物学，重点是碱基切除修复和核苷酸切除修复，2）表观遗传学在化学毒理学中的作用，3）纳米毒性的新兴问题，4）细胞色素P450结构，功能和机制，5）与细胞色素P450酶抑制和诱导有关的药物安全性预测。 近年来，化学界对这一竞技场技术发展的贡献大大增加，未来的增长只受到生物医学科学这一领域所涉及的大量学科之间缺乏相互交流的限制，因此需要举办这次专题讨论会。 来自不同学科的备受尊敬的科学家同意展示他们的最新发现。

DESCRIPTION (provided by applicant) This grant application requests funding for partial support of a series of symposia with the title "Frontiers in Chemical Toxicology". These symposia are part of the program to be presented by the American Chemical Society Division of Chemical Toxicology at the 236th National Meeting and Exposition of the Society in Philadelphia, Pennsylvania on August 17 through 21, 2008. These symposia will provide forums for the presentation of emerging research in key areas of chemical toxicology, including 1) the structural biology of DNA damage as related to repair, with emphasis on base excision repair and nucleotide excision repair, 2) the role of epigenetics in chemical toxicology, 3) emerging issues of nanotoxicity, 4) cytochrome P450 structure, function, and mechanism, and 5) drug safety prediction as related to cytochrome P450 enzyme inhibition and induction, to the chemical community. The contribution of the chemical community to the development of techniques in this arena has increased greatly in recent years, with future growth only limited by lack of cross-talk between the large numbers of disciplines involved in this area of the biomedical sciences, hence the need for this symposium. Highly respected scientists from a variety of disciplines have agreed to present their most recent findings.