The Mouse as an Instrument in Hearing Research III

描述(由申请人提供)：本申请为期一年，以支持将于2008年9月19-21日在缅因州巴尔港的杰克逊实验室(TJL)举行的“鼠标作为耳部研究的工具III”会议。我们目前正处于一场遗传学革命之中，这场革命有望将“突破性”生物医学研究推向新的水平。这场革命在很大程度上依赖于对基因之间的关系及其对复杂生物系统和表型的影响的分析。研究人员必须越来越熟练地应用遗传模型来解决各种重要的生物学问题。本次会议的目的是为从事听觉感觉神经生物学领域的研究人员和学生提供一个论坛。老鼠才刚刚开始被视为研究人类听觉系统的模型。因此，“老鼠作为耳朵研究的工具III”被设计成一个论坛，研究人员和学生可以在这个论坛上进一步研究实验室老鼠的巨大潜力。此外，使用鼠标的研究人员将能够扩大他们对该领域其他专家的技术知识，这些专家正在与其他模型合作，并对与模型系统之间的一致性和翻译有关的问题感兴趣。这次为期三天的会议包括几个教程和研讨会，旨在向与会者介绍现代分析方法，以及将实验室小鼠用作听觉研究的遗传工具。简短的演讲将详细说明教程中演示的技术，并提供前沿研究的例子。大多数演讲将由组织者邀请演讲，但也有时间来撰写论文和简短的摘要演讲。最终，这次会议将把具有不同专业知识和经验的学生和知名研究人员聚集在一起，讨论他们的研究成果，确定共同研究感兴趣的领域，并制定未来方向。对公众健康：这次会议与人类健康直接相关，因为它的重点是使用实验室小鼠来研究和了解人类听觉生物学和疾病。促进负责任地使用适当的模型对于开发有效的治疗人类疾病的新的治疗方法至关重要。

DESCRIPTION (provided by applicant): This application is for one year of support for the meeting "The Mouse as a Instrument for Ear Research III" to be held at The Jackson Laboratory (TJL) in Bar Harbor, Maine on September 19-21, 2008. We are currently in the midst of a genetics revolution that promises to push "breakthrough" biomedical research to new levels. A large part of this revolution depends upon the analysis of the relationships between genes and their effects on complex biological systems and phenotypes. Investigators must become increasingly skilled in the application of genetic models to address a variety of important biological questions. The objective of this meeting is to provide a forum for researchers and students who work in areas of audio-sensory neurobiology. The mouse is just beginning to be appreciated as a model for studying the human auditory system. "The Mouse as an Instrument for Ear Research III" is therefore designed as a forum in which researchers and students can further investigate the enormous potential of the laboratory mouse. In addition, researchers using the mouse will be able to expand their knowledge of techniques from other experts in the field working with other models and interested in issues relating to concordance between model systems and translation. This three-day meeting includes several tutorials and workshops designed to bring participants up to speed on contemporary methods of analysis and the use of the laboratory mouse as a genetic tool for auditory research. Short presentations will elaborate on techniques demonstrated in the tutorials and provide examples of cutting edge research. Most presentations will be invited lectures by the organizers but there are times available for contributed papers and short abstract talks. Ultimately, this meeting will bring students and established investigators with varying expertise and experience together to discuss their research findings, identify areas of common research interest and develop future directions. TO PUBLIC HEALTH: This meeting is directly relevant to human health as its focus is on the use of the laboratory mouse to study and understand human auditory biology and disease. Promoting the responsible use of appropriate models is critical to the development of effective new therapeutic approaches to treating human disease.