Signal Transduction Through Tetraspanins and Other Multi-Protein Cell Surface Com

描述（由申请人提供）：我们要求FASEB夏季研究会议的部分资金，题为“通过四跨膜蛋白和其他多蛋白质复合物的信号转导”，将于2008年6月22日至27日在耶鲁大学的Omni纽黑文酒店举行。四跨膜蛋白在广泛的基本细胞过程中发挥重要作用，包括运动、粘附、侵袭、细胞-细胞相互作用、融合、极性和受体运输。遗传学证据已经揭示了四跨膜蛋白在免疫、精卵融合、脑发育、细胞增殖控制、上皮完整性、突触形成和光感受器形态维持中的关键功能。此外，四跨膜蛋白已成为各种病理环境中的重要调节剂，包括肿瘤细胞转移、精神发育迟滞综合征、丙型肝炎病毒结合、HIV出芽和疟疾寄生虫入侵。四跨膜蛋白参与如此广泛的过程，因为它们充当细胞表面组织者，组装含有多种但特异性的细胞表面受体组、IG超家族蛋白和膜结合生长因子和蛋白酶的多蛋白复合物。因此，四跨膜蛋白的研究人员非常多样化，包括基础细胞生物学家，血管生物学家，发育生物学家，癌症生物学家，免疫学家，病毒学家，膜生物学家和神经生物学家。2008年FASEB四跨膜蛋白会议的目标是：（i）为四跨膜蛋白研究人员提供一个共同的论坛，由于该领域的多样性，他们可能不太可能参加相同的专业会议，（ii）在已建立的四跨膜蛋白研究人员和在其他环境中研究四跨膜蛋白伙伴的研究人员之间建立新的联系，（iii）培育更广泛的研究团体，以膜组织蛋白在信号转导中的作用为中心。为了实现这些目标，会议将有一个平衡的跨学科议程，包括九个主要会议，其中将在许多不同细胞类型和疾病状态的背景下探讨细胞表面组织的共同主题。因此，FASEB四跨膜蛋白会议将为科学互动、建立新的合作和交换有价值的研究试剂提供一个独特的机会，所有这些都有望加快四跨膜蛋白研究的生物医学重要领域的发现步伐。

DESCRIPTION (provided by applicant): We request partial funding for a FASEB Summer Research Conference entitled, "Signal Transduction through Tetraspanins and Other Multi-Protein Complexes," to be held June 22-27, 2008 at the Omni New Haven Hotel at Yale University. Tetraspanins play important roles in a wide range of fundamental cellular processes including motility, adhesion, invasion, cell-cell interactions, fusion, polarity, and receptor trafficking. Genetic evidence has uncovered critical functions for tetraspanins in immunity, sperm egg fusion, brain development, control of cell proliferation, epithelial integrity, synapse formation, and the maintenance of photoreceptor morphology. In addition, tetraspanins have emerged as important regulators in a variety of pathological settings, including tumor cell metastasis, mental retardation syndromes, hepatitis C virus binding, HIV budding, and malaria parasite invasion. Tetraspanins participate in such a broad range of processes because they act as cell surface organizers, assembling multi-protein complexes containing a diverse but specific set of cell surface receptors, Ig super family proteins, and membrane- bound growth factors and proteases. As a result, the tetraspanin researchers are extraordinarily diverse and include basic cell biologists, vascular biologists, developmental biologists, cancer biologists, immunologists, virologists, membrane biologists, and neurobiologists. The goals of the 2008 FASEB Tetraspanin Conference are (i) to provide a common forum for tetraspanin researchers who, owing to the diversity of the field, might otherwise be unlikely to attend the same professional meetings, (ii) to create new connections between established tetraspanin researchers and researchers studying tetraspanin partners in other contexts and, (iii) to foster a broader research community centered around the roles of membrane organizing proteins in signal transduction. To accomplish these goals, the meeting will have a balanced, interdisciplinary agenda with nine main sessions in which the common theme of cell surface organization will be explored in the context of many different cell types and disease states. The FASEB Tetraspanin Conference will thus provide a unique opportunity for scientific interaction, the establishment of new collaborations, and the exchange of valuable research reagents, all of which are expected to increase the pace of discovery in the biomedically important field of tetraspanin research.