2008 Biomolecular Interactions and Methods Gordon Research Conference

描述(由申请人提供)：本提案寻求对将于2008年1月13-18日在加利福尼亚州文图拉举行的戈登生物分子相互作用和方法研究会议的部分支持。这次会议的广泛和长期目标是促进我们对生物分子复合体的定量理解，以便我们可以表征生物功能、疾病和治疗干预的分子基础。2008年会议的主题是蛋白质相互作用动力学：理论、方法和实践，将探索表征蛋白质动力学的最新技术，蛋白质运动对结合相互作用的影响，以及生物系统中分子缔合的动力学。具体目标是召集来自计算生物学、生物物理学、化学和细胞生物学等学科的135名科学家，讨论数量生物学前沿的研究。该计划将涉及分子机器的组装、物理方法的进步、单分子动力学、酶动力学、蛋白质-药物相互作用、蛋白质波动对功能的影响、构象异质性和天然无序蛋白质以及蛋白质网络的动力学。David Baker博士(华盛顿大学)将就蛋白质复合体的计算设计发表主旨演讲。财政支持将包括赞助五名研究生和博士后研究员的注册，特别考虑第一次参加戈登会议的人、妇女、代表不足的少数群体和残疾人。这一建议意义重大，因为生物分子相互作用和方法戈登研究会议为科学家提供了一个独特的机会，让他们在以讨论为导向的会议上专注于蛋白质相互作用动力学这一高度跨学科的主题。这一应用与健康相关的是，生物分子相互作用是所有生物过程的基础，对这些过程的详细了解对于理解疾病的分子基础和开发新的治疗方法至关重要。 生物分子相互作用和方法戈登研究会议为来自生物物理、计算生物学、化学和细胞生物学学科的科学家提供了讨论数量生物学前沿研究的机会。这次会议讨论了研究两个或多个蛋白质之间、蛋白质与核酸(例如DNA)之间以及蛋白质与药物之间形成复合体的方法。由于所有生物过程都涉及分子之间的相互作用，因此了解这些相互作用对于理解疾病的分子基础和开发下一代治疗方法至关重要。

DESCRIPTION (provided by applicant): This proposal seeks partial support for the Gordon Research Conference on Biomolecular Interactions and Methods, which will take place on January 13 -18, 2008 in Ventura, California. The broad and long term goal of this meeting is to advance our quantitative understanding of biomolecular complexes so that we may characterize the molecular basis for biological functions, disease, and therapeutic intervention. The theme of the 2008 meeting, Protein Interaction Dynamics: Theory, Methods, and Practice, will explore the state-of-the-art for characterizing protein dynamics, the effect of protein motions on binding interactions, and the dynamics of molecular associations in biological systems. The specific aims are to assemble135 scientists from the disciplines of computational biology, biophysics, chemistry, and cell biology to discuss research on the forefront of quantitative biology. The program will address the assembly of molecular machines, advances in physical methods, single-molecule dynamics, enzyme dynamics, protein-drug interactions, the effect of protein fluctuations on function, conformational heterogeneity and natively disordered proteins, and the dynamics of protein networks. Dr. David Baker (University of Washington) will present a keynote address on the computational design of protein complexes. Financial support will include sponsoring the registration for five graduate students and postdoctoral fellows, giving special consideration to first-time Gordon Conference attendees, women, underrepresented minorities, and persons with disabilities. This proposal is significant because the Biomolecular Interactions and Methods Gordon Research Conference provides a unique opportunity for scientists to focus on the highly interdisciplinary subject of protein interaction dynamics in a discussion-oriented meeting. The health- relatedness of this application is that biomolecular interactions underlie all biological processes, and detailed knowledge of these processes is critical for understanding the molecular basis of disease and developing new therapies. The Biomolecular Interactions and Methods Gordon Research Conference provides the opportunity for scientists from the disciplines of biophysics, computational biology, chemistry, and cell biology to discuss research on the forefront of quantitative biology. This meeting addresses methods for studying the formation of complexes between two or more proteins, between proteins and nucleic acids (e.g. DNA), and between proteins and drugs. Since all biological processes involve interactions between molecules, understanding these interactions is critical for understanding the molecular basis for disease and for developing the next generation of therapies.