Targeting Bone Remodeling For the Treatment of Osteoporosis

6.项目总结/摘要 这是骨生物学领域的一个激动人心的时刻。在过去的几年里，我们 获得了对骨骼模型和重塑的深刻见解，这些信息已被应用于 涉及骨质疏松症和相关骨骼疾病的治疗。这样的知识已经延伸到 将自己带入几年前还无法理解的领域。比如说 骨细胞家族，即成骨细胞和破骨细胞，以前被认为在骨细胞中起作用。 骨重建单位内的音乐会，现在已经加入了骨细胞，一种新的细胞 被认为在这些细胞和其他系统的信号传导中起着关键作用。这些产品 骨细胞，也是最近认识到的，正在识别延伸到骨骼的过程和机制。 分子控制机制的核心这一新的知识已经跨越了很宽的范围 包括细胞和分子生物学，遗传学，流行病学，工程学， 生物力学、成像、材料科学、免疫学和综合器官生理学。沿着 与内分泌学和风湿病学等传统学科相比， 这个领域现在因这些其他领域的相互促进而丰富起来，产生了新的思想， 新知识因此，在这个时候举行一次会议是适当的， 可以考虑取得的进展，这些不同领域的专家可以聚集在一起。 这个想法是为了产生更多令人兴奋的想法和治疗骨质疏松症的方法， 这是导致我们老龄化人口残疾的主要原因。 我们认为，在这个时候，将临床、基础和翻译结合在一起是很重要的。 研究人员讨论这些新进展，以期具有治疗意义。 拟议的会议将成为将新知识转化为 新的治疗理念。此外，本次会议将确定未来的关键问题， research. 美国骨骼和矿物质研究协会是这项研究的首要协会， 促进与骨骼有关的疾病的基础和临床研究。的 上述考虑清楚地表明，这是高级思维的时候了。 领导者，职业中期的研究人员和年轻的研究人员聚集在一起，与NIH合作 研究所工作人员。在这种会议上交流的信息将有助于提供 美国国立卫生研究院与新的想法有关的计划值得支持，在未来几年，并导致一个充满活力的 交流思想，确定未来研究进展的重要途径， 治疗7.项目叙述 在过去的几年里，来自许多不同学科的科学家们为一个 我们在骨建模和骨重建方面的知识有了飞速的进步。我们 以几十年前做梦也想不到的方式了解骨骼是如何达到其大小的， 形状;它如何适应机械力的变化;它如何感觉到需要通过 在多细胞骨重建过程中， 单位;哪些细胞，分子和信号通路参与骨重建。这 知识已经迅速转化为对疾病的病理生理学的更好理解， 骨丢失、潜在遗传因素和疾病机制的阐明。提供 这些知识在临床竞技场中的应用对于治疗学来说是非常壮观的， 正在改变我们对骨质疏松症的看法， 这是衰老的必然结果现在，我们有药物可以防止骨质流失， 恢复骨量，可以刺激骨生长，可以改善微结构，可以实现 最终的终点，骨折风险的降低。但是，我们认识到，同时， 我们需要更全面地了解骨架的复杂性，以便使其更大 我们在真正治愈这种疾病的努力中取得了巨大的进步。这次会议的目的是 这些跨学科领域的专家聚集在一起，以确定未来的方向。

6. PROJECT SUMMARY/ABSTRACT This is a time of great excitement in the field of bone biology. In the past several years, we have gained great insight into how bone models and remodels, and this information has been applied to the treatment of osteoporosis and related skeletal disorders. Such knowledge has extended itself into areas that just a few years ago would have been incomprehensible. For example, the family of bone cells themselves, the osteoblast and the osteoclast, formerly thought to work in concert within the bone remodeling unit, now have been joined by the osteocyte, a cell newly recognized to play a pivotal role in signaling these cells and other systems. Products of these bone cells, also newly recognized, are identifying processes and mechanisms that extend to the very heart of molecular control mechanisms. This new knowledge has spanned a wide spectrum of disciplines that include cell and molecular biology, genetics, epidemiology, engineering, biomechanics, imaging, material sciences, immunology, and integrative organ physiology. Along with traditional areas that have housed the discipline, such as endocrinology and rheumatology, the field is now enriched with cross fertilization from these other areas, leading to new ideas and new knowledge. It is appropriate at this time, therefore, to hold a meeting in which these advances can be considered and in which experts in these various areas can gather together. The idea is to generate even more exciting ideas and therapeutic approaches to osteoporosis, which is a major cause of disability in our aging population. We believe it is important at this time to bring together clinical, basic and translational investigators to discuss these new advances with a view that will have therapeutic relevance. The proposed meeting will serve as an important step towards translating new knowledge into new therapeutic concepts. In addition, this meeting will identify key questions for future research. The American Society for Bone and Mineral Research is the premier society for the study and advancement of basic and clinical research in disorders relating to the skeleton. The considerations described above make it very clear that this is the time for senior thought leaders, mid-career investigators and young investigators to gather together in concert with NIH Institutes' staff. Information derived from the exchanges at such a meeting will serve to provide the NIH with novel ideas about programs worthy of support in future years and lead to a vibrant exchange of ideas and a definition of vital pathways for future advances in research and treatment. 7. PROJECT NARRATIVE Over the last several years, scientists from many different disciplines have contributed to an astonishingly fast improvement in our knowledge of bone modeling and bone remodeling. We understand, in ways never dreamed of several decades ago, how bone achieves its size and shape; how it adapts to changes in mechanical forces; how it senses the need to renew itself by breaking down old bone and replacing it with new bone within the multi-cellular bone remodeling unit; what cells, molecules and signaling pathways are involved in bone remodeling. This knowledge has been translated rapidly into greater understanding of the pathophysiology of bone loss, underlying genetic factors and elucidation of disease mechanisms. The delivery of this knowledge to the clinical arena has been nothing short of spectacular with therapeutics that are transforming how we think of a disease like osteoporosis, that not too long ago was viewed as an inevitable consequence of aging. Now, we have drugs that can prevent bone loss, can restore bone mass, can stimulate bone growth, can improve microarchitecture and can achieve the ultimate end point, the reduction of fracture risk. But, we recognize, at the same time, the need to understand more completely the skeleton in its complexity so as to make even greater strides in our attempt to literally cure this disease. The purpose of this meeting is to bring together experts from these interdisciplinary fields so as to define the direction of the future.