MAMMARY GLAND BIOLOGY GRC

简介（由申请人提供）：戈登乳腺生物学研究会议计划于2007年6月，2008年6月和2009年6月在Salve Regina大学（2007年和2009年）和意大利Il Ciocco（2008年）举行。这些会议包括正常乳腺生物学和乳腺癌。鉴于乳腺癌在美国和西方世界的惊人发病率，这些话题目前是密集调查的焦点。此外，母乳喂养对婴儿和母亲的好处已经变得越来越明显，因此，哺乳的生物学对人类健康很重要，而不仅仅是乳制品行业。乳腺生物学领域包括发育、激素作用、细胞内信号、泌乳与分泌、衰老与凋亡、乳腺癌危险因素、乳腺癌实验模型以及基础研究向临床的转化。会议计划将包括这些专业领域的前沿演讲者，并将旨在促进不同学科的研究人员之间的互动，以促进与乳腺生物学相关的所有领域的进展。

DESCRIPTION (provided by applicant): Gordon Research Conferences on Mammary Gland Biology are planned for June 2007, June 2008, and June 2009 at Salve Regina University (2007 and 2009) and Il Ciocco, Italy (2008). These meetings encompass both normal mammary gland biology and breast cancer. These topics are currently the focus of intense investigation given the alarming rate of breast cancer in the United States and the western world. Furthermore, the benefits of breast feeding for both the infant and mother has become more apparent, and thus the biology of lactation is important to human health, and not just the dairy industry. The mammary gland biology field includes development, hormone action, intracellular signaling, lactation and secretion, involution and apoptosis, risk factors for breast cancer, experimental models of breast cancer, and translation of basic research to the clinic. Conference programs will include speakers that are at the leading edge of these specialized areas, and will be designed to foster interactions between investigators across different disciplines to enhance advances in all areas related to mammary gland biology. Because of recent advances in genomics, proteomics, and metabolomics, the 2007 meeting will focus on integrating the development of the mammary gland with molecular physiology so functional outcomes can be appreciated in a larger context. Such an integrated approach is critical for developing new models of the mammary gland which expand upon a growing knowledge base of experimental models of normal function, and dysfunction including breast cancer. Topics for sessions include early development, stem cells in development and cancer, lactation, involution, tumor metabolism (the molecular basis underlying the Warburg effect), models of cancer, and translation of basic science advances to the clinic. The opening keynote address will focus on genes that regulate metastasis of breast cancer cells and imaging of this process in vivo. The closing address will develop a view of mammary gland physiology by integrating historical data with recent advances that probe the molecular basis for mammary gland development and function. The Mammary Gland Biology Gordon Conference is the premier conference in the field that stimulates cross-disciplinary interaction and supports career development of junior investigators and trainees.