Obesity on Vagal Tone and HbA1c during Pregnancy

肥胖是许多不良妊娠的原因。 因此，对妇女及其子女的健康有很大的影响。 据推测，肥胖女性在怀孕期间会增加糖化血红蛋白，减少迷走神经 与非肥胖女性的反应和氧合作用进行比较。来自四个主要民族的40名孕妇 在怀孕20周、28周和36周时，每组20名肥胖患者，观察三次，每次30分钟 以及由他们的体重指数决定的非肥胖状态。观察的时间点一直是 之所以选择，是因为20周后，如果出生，胎儿可以存活；28周时，胎儿如果出生，将是 早产，在这个阶段，母体疾病，如高血压或糖尿病，可能成为临床上的 明显表现为妊娠压力和妊娠体重增加；36周时胎儿将接近 到足月出生。在妊娠并发症和婴儿结局之后，将进行图表审计和访谈 受试者的。暂定分析计划将包括描述性统计、两组比较的t检验、 并且，重复测量ANOVA来测试随时间变化的组差异。相关性和 将进行回归分析，以检验肥胖与妊娠水平之间的关系。 体重增加对迷走神经反应、糖化血红蛋白、氧合作用、妊娠并发症和出生结局的影响。 如果效应大小为1，17，则需要被试以80%的能力来检测差异。考虑 20%的流失率[如早产可能发生的那样，每组20名妇女被提议。

Obesity is the cause of many adverse pregnancy outcomes and as a result, has a great impact on the health of women and their children. It is hypothesized that during pregnancy obese women will have increased HbA1c, decreased vagal response and oxygenation compared to non-obese women. Forty pregnant women of four major ethnic groups will be observed three times for 30 minutes at 20, 28, and 36 weeks gestation, 20 each with obese and non-obese status determined by their body mass index. The time points for observation have been selected because after 20 weeks the fetus could be viable if born; at 28 weeks the fetus if born would be preterm and at this stage, maternal disorders such as hypertension or diabetes may become clinically apparent with the stress of pregnancy and gestational weight gain; and at 36 weeks the fetus will be close to term birth. Pregnancy complications and infant outcomes will be followed by chart audits and interviews of subjects. The tentative analysis plan will include descriptive statistics, t-tests for two group comparisons, and, repeated measures ANOVA to test the group differences with changes over time. Correlations and regression analyses will be performed to examine the association of obesity and levels of gestational weight gain on vagal response, HbA1c, oxygenation, and pregnancy complications and birth outcomes. For an effect size of 1, 17subjects will be needed to detect a difference with a power of 80%. Considering a 20% attrition rate [as may occur with preterm birth, 20 women per group is proposed.