Efficacy of Laryngeal High-Speed Videoendoscopy

描述（由申请人提供）：发声障碍是由于发声过程中正常声带振动的中断而引起的。目前评估声音障碍的金标准是通过视频频闪检查进行内窥镜检查。然而，频闪成像固有的技术限制（即，产生通过多个振动周期组装的合成图像）限制了视频频闪成像的临床和研究用途。高速成像有可能捕捉到声带真实的周期到周期的振动行为，这应该在理论上克服视频频频检查的局限性，并提供更准确客观量化声带振动行为的潜力。声带高速成像有很长的研究历史，并且相对最近的商业介绍喉部高速视频内窥镜（HSV）已经有助于增加其临床和研究应用的可用性。然而，这些HSV系统还没有得到广泛采用，因为仍然存在方法上的局限性(例如：图像质量受损；缺乏工具来提取丰富的视觉内容，难以管理和分析HSV产生的大量数据，等等)，以及缺乏与HSV的有效性、实用性和临床相关性相关的信息。本项目的主要目的是开发改进的基于单纯疱疹病毒的声带振动特征可视化和自动测量方法，以促进该技术的临床和研究应用，并开始建立单纯疱疹病毒在声带病理功能评估中的临床有效性、实用性和相关性。最重要的假设是，HSV可以发展成为一种强大的工具，它将为喉发声的生物力学提供新的见解（特别是当与其他同步测量相结合时），以及能够更准确地评估声音障碍的病理生理功能，从而在声带病理诊断中得到重要的改进。主要目的是通过一系列实验来完善HSV技术，发展分析技术，建立临床方案，收集数据，评估HSV在嗓音障碍临床评估中的可靠性、有效性和相关性。该项目提出了一种全面的方法，通过领先的科学家和临床医生的合作来解决上述所有任务。

DESCRIPTION (provided by applicant): Voice disorders result from the disruption of normal vocal fold vibration during phonation. The current gold standard for assessing voice disorders is visual endoscopic examination via videostroboscopy. However, technical limitations that are inherent to stroboscopic imaging (i.e., generating a composite image that is assembled across many cycles of vibration) restrict the clinical and research utility of videostroboscopy. High-speed imaging has the potential to capture the true cycle-to-cycle vibratory behavior of the vocal folds, which should theoretically overcome the limitations of videostroboscopy, and provide the potential for more accurate objective quantification of vocal fold vibratory behavior. Vocal fold high-speed imaging has a long research history, and the relatively recent commercial introduction of laryngeal high-speed videoendoscopy (HSV) has served to increase its availability for clinical and research use. However, these HSV systems have not gained widespread adoption because of remaining methodological limitations (eg., compromised image quality; lack of tools to extract the rich visual content, difficulty managing and analyzing the massive amounts of data generated by HSV, etc.), and an associated lack of information regarding the validity, practicality, and clinical relevance of HSV. The primary purpose of this project is to develop improved HSV-based methods for the visualization and automatic measurement of vocal fold vibratory characteristics that will facilitate the clinical and research use of this technology, and to begin establishing the clinical validity, practicality, and relevance of HSV in the functional evaluation of vocal fold pathology. The overriding hypothesis is that HSV can be developed into a robust tool that will provide new insights into the biomechanics of laryngeal sound production (particularly when combined with other simultaneous measures), as well as enable more accurate functional assessment of the pathophysiology of voice disorders leading to important refinements in the diagnosis of vocal fold pathology. The primary purpose requires a series of experiments to improve HSV technology, develop analysis techniques, establish a clinical protocol, collect data, and evaluate the reliability, validity, and relevance of HSV in the clinical assessment of voice disorders. This project proposes a comprehensive approach addressing all of the above tasks, through the collaboration of leading scientists and clinicians.