Administrative and Mouse Management Core

概述。如前所述，此核心由两个组件组成： 一个常规管理组件和一个鼠标管理组件。 一般管理部分的工作是维护整个方案及其 通过组织小组会议、静修和日记俱乐部以及处理任何和所有 出现的部门或机构问题。它还组织对该计划的内部和外部审查， 以及确保及时提交续签申请。它定期跟踪 每月提供项目的财务状况，并协助解决招聘和其他人事问题。在……里面 此外，核心确定了与计划相关的新出版的文献，并将其分发给 项目内适当的调查人员。管理组件的目标是确保 整个程序尽可能高效和优化地运行。 鼠标管理部分支持1名全职和1名兼职动物技术员。这些 经过充分培训并从事基因靶向和转基因小鼠的维护工作的个人 在个别项目中提出的模型。此组件在一个 无病原体的小鼠特异性隔膜，如下所述。新鼠标型号的实际生产将是 通过目前建立的UCSD转基因小鼠和胚胎干细胞基因打靶完成 CORE，请参阅http://cancer.ucsd.edu/Research/Shared/tgm/default2.asp.这座最先进的设施是 最初是在J.Marth(项目1负责人)的大力支持和建议下开始的，后来开发了 在转基因小鼠的生产方面有出色的记录。因此，与其进行基因打靶，不如 对于我们自己来说，现在这个计划通过按服务付费的方式为老鼠的生成支付费用是有意义的 这就建立了UCSD Core。虽然总成本大致相同，但我们在 机构。由于我们过去使用这种方法的经验很好，我们决定在 目前的建议。 预算方法：根据我们迄今的经验，我们也认为最好保持日常管理 和饲养小鼠，涉及的动物技术人员，小鼠笼子空间的成本，以及使用 将这样的速度遗传(见下文)作为核心职能-而不是为每个人分配资源 这些活动的项目。此方法还允许最大限度地灵活地满足以下需求 所有项目，每年都会有所不同。虽然这使得一个相当大的预算 “行政核心”，大部分预算其实都是鼠标相关的费用。管理组件 预算与前一次赠款的预算大体相同。

Overview. As before, this Core consists of two components: A General Administrative Component, and a Mouse Management Component. The General Administrative Component works to maintain the cohesiveness of the whole program and its functions by organizing group meetings, retreats and journal clubs, and by dealing with any and all inter- Departmental or Institutional issues that arise. It also organizes internal and external reviews of the program, as well as making sure that renewal applications are submitted in a timely fashion. It regularly tracks the financial status of the program on a monthly basis, and assists in hiring and other personnel issues. In addition, the Core identifies newly published literature relevant to the program, and distributes to the appropriate investigators within the program. The goal of the administrative component is to make certain that the entire program functions as efficiently and optimally as possible. The Mouse Management Component supports 1 full time and one part-time animal technician. These individuals who are fully trained and engaged in the maintenance of gene-targeted and transgenic mouse models proposed in the individual projects. This component has the necessary equipment and space in a pathogen-free mouse-specific vivarium, as detailed below. The actual production of new mouse models will be done through the currently established UCSD Transgenic Mouse and Embryonic Stem Cell Gene Targeting Core, please see http://cancer.ucsd.edu/Research/Shared/tgm/default2.asp. This state-of-the-art facility was originally started with major support and advice from J. Marth (Project 1 leader) and has since developed an excellent track record in the production of genetically altered mice. Thus, rather than doing gene targeting ourselves, it now makes sense for this program to pay via fee-for-service for the generation of mice through this established UCSD Core. While the total costs are about the same, we avoid duplicative functions at the institution. Since our past experience with this approach has been good, we have decided to continue it in the current proposal. Budgetary Approach: Based on our experience to date, we also feel it is best to keep the daily management and breeding of mice, the animal technicians involved, the costs of mouse cage space, and the use of approaches such a Speed Congenics (see below) as a Core function - rather than allocating resources to each project for these activities. This approach also allows the maximum flexibility in accommodating the needs of all the projects, which will vary from year to year. While this makes for a rather large budget for an "Administrative Core", most of the budget is actually for mouse-related costs. The administrative component budget remains very much the same as in the previous version of the grant.