CORE--ANIMAL MODELS

本核心的目的是提供跨学科动物模型的一致性制备。 各种项目。本中心负责制备慢性动物模型， 个体研究者使用。这将减少准备工作的可变性，并将使各个项目总监从创建这些准备工作和照顾术后立即恢复的极端劳动密集型任务中解放出来。Core还将提供心力衰竭或假手术时间对照发生之前和期间动物的超声心动图数据。将由康沃尔语博士或在其指导下制备各种动物模型，Cornish博士在慢性动物制备方面具有多年经验，并且在这些特定动物制备方面具有丰富经验。在动物被各研究者使用之前，他将在两名技术人员的协助下准备和护理动物。本中心制备的模型为：（1）大鼠冠状动脉结扎心力衰竭（HF）模型;（2）家兔HF起搏模型。在过去几年PPG的开发过程中，使用声测显微晶体提供心室功能相关信息已转变为使用超声心动图数据。这一方法最初是在朱克博士的实验室里进行的，但现在也被其他实验室更广泛地使用。由于只有一台超声心动图机可用，该功能现在将成为动物核心的一部分。Ms. Hallelu-Golka将加入核心，主要负责在心力衰竭诱导之前、期间和之后获得大鼠和家兔的数据。在Kaye Talbitzer的协助下，Hallele-Golka女士现在将为其他项目提供这项服务。

The purpose of this Core is to provide for the consistent preparation of animal models across the various projects. It will be the responsibility of this Core to prepare the chronic animal models for individual investigator use. This will reduce the variability of preparations and will release the individual project directors from the extremely labor intensive task of creating these preparations and caring for their immediate post operative recovery. The Core will also provide echocardiograph data on the animals prior to and during the development of heart failure or sham time controls. The various animal models will be prepared by or under the direction of Dr. Cornish who has had many years of experience in the preparation of chronic animals and is experienced in these specific animal preparations. He will be assisted by two technicians in the preparation and care of the animals prior to their use by the various investigators. The models prepared by this core will be (1) the coronary ligation model of heart failure (HF) in the rat, and (2) the pacing model of HF in the rabbit. During the development of the PPG over the past years, the use of the sonomicrometry crystals for providing information relative to ventricular function has shifted to the use of echocardiographic data. This began with work in Dr. Zucker's laboratory but is now being used more generally by the other labs as well. Since there is only one echocardiogram machine available, this function will now become part of the animal core. Ms. Hallgren-Golka will be joining the Core and has been primarily responsible for obtaining data on rats and rabbits prior to, during and after the induction of heart failure. Ms. Hallgren-Golka, with the assistance of Kaye Talbitzer, will now provide this service to the other projects.