Predoctoral Training Program in Molecular Pharmacology

描述（由申请人提供）：梅奥研究生院分子药理学和实验治疗学（MPET）博士培训计划的主要目标是培养能够指导学术界，工业界或其他环境中杰出研究项目的独立研究人员。该学院由18名资金充足的独立研究人员组成，他们专注于从疾病的基本分子和遗传方面的研究，通过药物发现和心血管、神经退行性疾病和恶性疾病的新疗法的开发。该学院提供的培训领域包括计算化学、药物作用和耐药性的分子机制、新型治疗策略、临床前和临床药理学以及与药物反应相关的基因的药物基因组学。目前有21名博士在读生在生物医学科学博士项目的MPET轨道上。严格的教学课程包括一系列核心课程，确保学生在生物化学、分子生物学、遗传学、统计学、细胞生物学和药理学方面有扎实的基础知识，以及一系列以辅导为基础的课程，为学生提供分子药理学方面的高级培训。在前两年的学习中，学生要完成3个实验室轮转，并选择一个实验室进行论文研究。他们在第二年结束时参加全面的书面和口头资格考试。在制定论文书面提案描述论文研究中要追求的问题和方法后，论文委员会在第一次委员会会议上审查拟议的研究。学生每年向MPET教师和学生展示他们研究项目的最新进展。我们强烈鼓励学生及时出版已完成的作品，并参加全国性的会议来展示他们的作品。完成博士课程的平均时间约为4.8年。在第四年和第五年的培训中，指导学生确定优秀的博士后培训机会，作为他们职业发展的下一步。MPET博士培训项目的毕业生有着出色的业绩记录，其中许多人现在担任首席研究员，指导他们自己的实验室。

DESCRIPTION (provided by applicant): The primary goal of the Ph.D. Training Program in Molecular Pharmacology and Experimental Therapeutics (MPET) in the Mayo Graduate School is the development of independent investigators capable of directing outstanding research Programs in academia, industry or other settings. The faculty is comprised of 18 well funded, independent investigators, who focus on a continuum of research encompassing studies from basic molecular and genetic aspects of disease through drug discovery and development of novel therapies for cardiovascular, neurodegenerative and malignant diseases. This faculty provides training opportunities in areas that include computational chemistry, molecular mechanisms of drug action and resistance, novel therapeutic strategies, preclinical and clinical pharmacology, and pharmacogenomics of genes associated with drug responses. Twenty-one predoctoral students are currently enrolled in the MPET track of the Biomedical Sciences Ph.D. Program. A rigorous didactic curriculum includes a series of Core Curriculum courses that ensures a strong fundamental knowledge in biochemistry, molecular biology, genetics, statistics, cell biology and pharmacology and a series of tutorial-based courses to provide students with advanced training in molecular pharmacology. During their first two years of study, students complete 3 laboratory rotations and select a laboratory for their thesis research. They sit for comprehensive written and oral qualifying examinations at the end of year two. After developing a thesis written proposal delineating the questions and approaches to be pursued in the thesis research, the thesis committee reviews the proposed research at the first committee meeting. Students present work-in-progress updates on their research projects to MPET faculty and students each year. Students are strongly encouraged to publish completed work in a timely manner and to attend national meetings to present their work. The average time to completion of the Ph.D. Program is approximately 4.8 years. During the fourth and fifth years of training, students are mentored to identify outstanding postdoctoral training opportunities as the next step in their career development. Graduates of the MPET Ph.D. training program have outstanding track records, with many now serving as principal investigators directing their own laboratories.