Role of the Gut in Post-Injury Multiple Organ Failure

描述（由申请人提供） 项目摘要：该培训计划的长期目标是培养具有学术竞争力的创伤学专家，他们可以设计和执行实验室模型来测试临床相关假设，与其他类型的科学家合作，以提高对他们正在研究的问题的基本理解，并将这些信息转化回临床竞技场。该计划主要来自参与NIGMS赞助的德克萨斯大学休斯顿医学院创伤研究中心（TRC）的教师和研究实验室。该计划主要招募医学博士（主要是外科医生），他们有兴趣将创伤相关研究作为职业目标。学员将沉浸在一个综合的研究工作，继续发展的TRC追求其研究主题，阐明胃肠道在多器官衰竭的发病机制的作用。该计划的行政结构是由计划主任（弗雷德里克A。摩尔，医学博士），副项目主任（大卫W。美世，医学博士）和执行委员会。每个学员都有一个主要的导师。导师负责帮助学员1）制定一个有针对性的研究计划，2）获得必要的实验室用品，设备和技术指导，以执行所需的实验，3）分析结果，得出结论，并修改实验策略，以及4）组织口头和书面陈述。培训计划的基石是真理与和解委员会的每周星期五会议，学员介绍他们不断发展的研究，并通过例子学习如何批评和修改研究提案。此外，学员参加正式的课程工作，包括1）外科研究研讨会的基础，2）临床研究课程，3）生物医学科学的伦理维度，和4）实验室动物医学和护理研究中心培训课程。学员将提交摘要并在国家会议上展示他们的数据，为同行评审的出版物准备手稿，并介绍与他们的研究相关的外科大圆桌讲座。在为期两年的培训计划结束时，学员将能够撰写具有竞争力的研究提案。 相关性：创伤是一个严重的卫生保健问题。它是第三大死亡原因（仅次于心脏病和癌症），也是长期残疾的主要原因。该计划将培养未来的临床科学家，他们将与其他类型的科学家合作，增加对创伤相关疾病的基本了解，并将这些信息带回床边，以改善对严重受伤患者的护理。

DESCRIPTION (provided by applicant) Project Summary: The long-term objective of this training program is to produce academically competitive traumatologists who can design and execute laboratory models to test clinically relevant hypotheses, collaborate with other types of scientists to enhance the basic understanding of the problem they are studying and translate this information back to the clinical arena. The program is primarily derived from the faculty and research laboratories that participate in the NIGMS-sponsored Trauma Research Center (TRC) at the University of Texas-Houston Medical School. The program recruits primarily MDs (principally surgeons) who are interested in pursuing trauma related research as a career goal. The trainees will be immersed into an integrated research effort that continues to evolve as the TRC pursues its research theme of elucidating the role of the gastrointestinal tract in the pathogenesis of multiple organ failure. The administrative structure of the program is coordinated by the Program Director (Frederick A. Moore, MD), Associate Program Director (David W. Mercer, MD), and the Executive Committee. Each trainee has a primary mentor. The mentor is responsible for helping the trainee 1) formulate a focused research proposal, 2) access laboratory supplies, equipment and technical instruction necessary to perform the required experiments, 3) analyze the results, develop conclusions, and revise experimental strategies, and 4) organize both oral and written presentations. The cornerstone of the training program is TRC's weekly Friday meetings where the trainees present their evolving research and learn by example how to critique and modify research proposals. Additionally, the trainees participate in formal course work including 1) Fundamentals of Surgical Research Workshop, 2) Clinical Research Curriculum, 3) The Ethical Dimensions of the Biomedical Sciences, and 4) Center for Laboratory Animal Medicine and Care Research Training courses. The trainees will submit abstracts and present their data at national meetings, prepare manuscripts for peer-reviewed publication, and present a Surgical Grand Rounds lecture related to their research. At the end of the two-year training program, the trainee will be capable of writing a competitive research proposal. Relevance: Trauma is a serious health care problem. It is the third leading cause of death (behind heart disease and cancer) and is the leading cause of long-term disability. This program will train the future clinical scientists who will work with other types of scientists to increase basic understanding of trauma related illness and take this information back to the bedside to improve the care of severely injured patients.