PROGRAM IN HUMAN AND MOLECULAR GENETICS

描述（由申请人提供）：这是一份申请，旨在继续支持贝勒医学院分子与人类遗传学（DMHG）的人类和分子遗传学博士前项目。该计划的总体目标是培养博士预科学生在遗传学和分子生物学的基础方面，重点是未来生物医学研究领域的最新研究。培训教员总数为59人，大致分为正教授、副教授和助理教授。所有学院都拥有独立的、资金充足的实验室，在遗传学和分子遗传学的广泛领域与人类和重要的模型系统进行研究。主要研究领域包括克隆人类疾病基因、突变分析、基因组印迹、体细胞基因治疗、小鼠和果蝇发育生物学研究、小鼠遗传学新技术开发、细胞周期控制、染色体组织和维持、细菌重组、基因组测序和神经系统疾病遗传学。这是一个快速扩展的项目，拥有优秀的教育和研究支持设施，位于一个正在积极发展和改进的机构内。学生培训包括一整年的教学课程、期刊俱乐部和研究轮转，以拓宽他们的背景，并为他们选择实验室进行论文研究提供坚实的基础。接下来是第二年的口头资格考试，平均四年的实际实验室研究，并坚定地承诺发表。DMHG目前有76名学生，预计从2005- 2006学年开始将增加12名学生。近十五年来，该系共培养博士研究生80人，这些博士生目前正在从事博士后培训或进入生物技术产业界或学术界从事研究工作。

DESCRIPTION (provided by applicant): This is an application for continued support for the predoctoral program in human and molecular genetics based in the Department of Molecular and Human Genetics (DMHG) at Baylor College of Medicine. The overall goal of this program is to train predoctoral students in fundamental aspects of genetics and molecular biology with strong emphasis on state-of-the-art research for future careers in biomedical research. The total number of training faculty is 59, approximately split between full professors, associate professors and assistant professors. All faculty maintain independent well-funded laboratories conducting research in broad areas of genetics and molecular genetics with humans and important model systems. Major research areas include cloning human disease genes, mutation analysis, genomic imprinting, somatic gene therapy, the study of mouse and Drosophila developmental biology, development of new technologies for mouse genetics, control of cell cycle, chromosome organization and maintenance, bacterial recombination, genomic sequencing, and genetics of neurological disorders. This is a rapidly expanding program with excellent support facilities for education and research located within an institution undergoing an aggressive program of growth and improvement. Student training consists of a full year of didactic coursework, journal clubs and research rotations to broaden their backgrounds and provide them with a solid basis for selection of a laboratory in which to conduct their dissertation research. This is followed by an oral qualifying exam in year two and an average of four years of actual laboratory research, with a strong commitment to publication. Currently there are 76 students in the DMHG with an additional 12 students expected to begin with the 2005- 2006 academic year. The department has graduated 80 students with a Ph.D. degree in the past fifteen years who are now in postdoctoral training or have entered research positions in the biotechnology industry or academia.