Linking Clinical Phenotypes and Molecular Underpinnings of Addiction

描述(由申请人提供)： 培训医生更好地理解和治疗成瘾障碍对NIDA的使命至关重要。尽管神经科学最近取得了重大进展，但由于临床/生物学相关性的不完全阐明以及缺乏受过科学培训的成瘾精神病学家，应用于实践的能力一直受到限制。我们提出了成瘾精神病学跨学科研究培训(APIRT)计划，这是一个由研究密集型范德比尔特大学医学中心(VUMC)和历史上一直是非裔美国人的Meharry医学中心(MMC)组成的联盟，旨在为成瘾精神病学家提供培训，在这个临床实践、神经成像方法和强大的遗传范式日益专业化的时代，所有这些都是在高通量分子技术和信息科学前所未有的进步的背景下开始临床/研究生涯的。我们每年寻求两名学员的支持，分别来自MMC和VUMC精神病学系，在协调的学术丰富的成人和成瘾精神病学培训轨道之外进行为期两年的学习，最终获得临床调查科学硕士(MSCI)。对于MSCI，学员必须完成一个跨学科的临床研究项目，严格的教学方法，以及申请继续为NIDA提供研究支持。APIRT项目还为受训者提供了独特的实验室接触，帮助他们了解基础研究的范围(潜力和局限性)，而不是成为基础研究人员的能力。学员还将接受个性化生物统计和生物信息学培训，以及由参与单位主办的跨学科培训。APIRT计划的目标是提供培训，在跨学科团队中，在现实世界中使用高性能计算研究方法，研究临床观察和来自神经成像和基因组学/蛋白质组学新兴技术的生物数据之间的联系，以完善成瘾和共生疾病患者的诊断和治疗。APIRT得到了一个由NIDA和其他NIH支持的研究人员互动小组的支持，完善和随时可用的研究核心计划，以及对Meharry/Vanderbilt联盟的坚定承诺，该联盟的重点是研究、教学和临床护理，以解决医疗保健差距，并从代表不足的少数族裔人口中培养学术领袖。

DESCRIPTION (provided by applicant): Training physicians to better understand and treat addictive disorders is vital to the mission of NIDA. In spite of significant recent advances in neuroscience, applications to practice have been limited by incomplete elucidation of clinical/biological correlates and a paucity of addiction psychiatrists with scientific training. We propose the Addiction Psychiatry Interdisciplinary Research Training (APIRT) Program, a consortium between the research intensive Vanderbilt University Medical Center (VUMC) and the historically African American Meharry Medical Center (MMC), to provide training for addiction psychiatrists embarking on combined clinical/research careers in an era of increasingly specialized clinical practice, neuroimaging approaches, and powerful genetic paradigms, all in the context of high throughput molecular technologies and unprecedented advances in information science. We seek support for two trainees per year, one each from MMC and VUMC Departments of Psychiatry, for a two year course of study beyond a coordinated academically enriched Adult and Addiction Psychiatry training track, leading to the Master of Science in Clinical Investigation (MSCI). For the MSCI, trainees must complete an interdisciplinary clinical research project, rigorous didactics, and an application for continued research support to NIDA. The APIRT program also offers unique laboratory exposure to trainees that foster an understanding of the scope (potential and limitations) of fundamental research, rather than the capacity to become basic researchers. Trainees will also receive individualized biostatistical and bioinformatics training, and interdisciplinary training sponsored by the participating units. The objective of the APIRT Program is to provide training to meaningfully investigate - in interdisciplinary teams, using high-performance computing research methodologies in real world settings - the linkages between clinical observations and biological data from emerging technologies in neuroimaging and genomics/proteomics for refining diagnosis and treatment of patients with addiction and co-occurring disorders. APIRT is enhanced by an interactive group of investigators with NIDA and other NIH support, well-established and readily available research core programs, and a strong commitment to the Meharry/Vanderbilt Alliance, with its emphasis on research, teaching, and clinical care to address health care disparities and developing academic leaders from under-represented minority populations.