Research Training in Alimentary Tract Surgery

该计划为年轻外科医生提供研究培训，他们计划在以下领域进行患者护理和调查 消化道的外科问题。它的主要目的是让这些人做好准备，成为 独立资助的调查人员。该计划提供密集的、协调的基础研究培训 分子和细胞生物学、生物化学和生物物理学、器官生理学和病理生理学，以及 免疫学，因为它们适用于消化道、肝胆系统和胰腺疾病。第一笔资金来自 1997年是布里格姆妇女医院外科部门与 前贝丝以色列医院，该计划现在扩大到包括NIH资助的外科研究实验室， 哈佛医学院所有主要成人教学医院的附属医院。核心部门目前的调查领域 感受者组包括：1)胃肠粘膜分泌和屏障功能(Soybel、Hofer、Hagen)； 败血症和休克时肝脏的能量和代谢紊乱(Fischer，Hasselgren)；3)肠道分化 和对饥饿或大规模切除的生长反应(Hodin，Ashley，Zner)；4)细胞生物学和 急性和慢性胰腺炎的病理生理学(Warshaw)；5)胰腺癌生长的分子基础和 转移(Callery)；6)组织工程学在消化道重建和康复中的应用 (瓦康蒂，Wang)；和7)评价结果和在业务中引入新技术 消化系统(Zner，Warshaw，Daley)。此外，还招募了一些年轻的教职员工。 HMS不同的外科科室，旨在将他们发展为该领域的外科医生和研究人员 胃肠道和HPB手术。我们建议在明确规定的情况下，将这些年轻教员包括在内，作为共同 我们的研究员的导师，从而改善了学习环境，并提供了一个 为未来的导师提供指导。该计划将通过提供BASIC课程的正式课程而得到丰富 哈佛医学院和公共卫生学院的科学和实验技术，通过互动 与美国国立卫生研究院资助的消化疾病中心(HMS和MGH)的核心实验室和研究人员合作， 并通过参加每个机构提供的临床和研究会议。培训计划 执行委员会(Soybel、Hodin、Hasselgren)监督选拔受训人员、指定教务长、 规定正规课程，并让受训人员参与讲授道德和责任的课程 研究中的行为。实习生是通过一个向外科住院医师或经认证的研究员开放的程序来挑选的 美国外科住院医师培训计划。主动寻求个人申请的程序 属于代表性不足的少数群体，通过卫生与公众服务部的多样性办公室和每个 参与机构的名单。

This Program provides research training for young surgeons who plan careers for patient care and investigation in surgical problems of the alimentary tract. Its primary purpose is to prepare these individuals to become independently funded investigators. The program provides intensive, coordinated research training in fundamental aspects of molecular and cell biology, biochemistry and biophysics, organ physiology and pathophysiology, and immunology, as they apply to diseases of the alimentary tract, hepatobiliary system and pancreas. First funded in 1997 as a collaboration between the Departments of Surgery at the Brigham and Women's Hospital and the former Beth Israel Hospital, this program is now expanded to include NIH-funded surgical research laboratories at all major adult teaching hospital affiliates of Harvard Medical School. Current areas of investigation by core preceptor group include: 1) gastro-intestinal mucosal secretion and barrier function (Soybel, Hofer, Hagen); 2) energetics and metabolic derangements of liver in sepsis and shock (Fischer, Hasselgren); 3) gut differentiation and growth responses to starvation or massive resection (Hodin, Ashley, Zinner); 4) cell biology and pathophysiology of acute and chronic pancreatitis (Warshaw); 5) molecular basis of pancreatic cancer growth and metastasis (Callery); 6) tissue engineering as applied to reconstruction and rehabilitation of the alimentary tract (Vacanti, Whang); and 7) evaluation of outcomes and introduction of new technologies in operations on the Digestive System (Zinner, Warshaw, Daley). In addition, a number of young faculty have been recruited to the different Departments of Surgery at HMS, with intention of their development as surgeon-investigators in the field of GI and HPB Surgery. We propose to include these young faculty, under clearly specified circumstances, as co- mentors of our research fellows, thereby enhancing the environment for learning and providing an environment of mentoring for future mentors. The program will be enriched by opportunties for formal coursework in basic sciences and experimental techniques at Harvard's Medical School and School of Public Health, by interactions with core labs and investigators of the NIH-funded Digestive Diseases Centers (HMS-based and MGH-based), and by participation in clinical and research conferences offered at each institution. The training Program Executive Committee (Soybel, Hodin, Hasselgren) oversees selection of trainees, designation of precptors, prescription of formal coursework, and participation of trainees in programs teaching ethics and responsible conduct in research. Trainees are selected through a process open to surgical residents or fellows in accredited U.S. Surgical Residency Training Programs. A pro-active process for seeking applications from individuals belonging to under-represented minority groups is coordinated through the Offices for Diversity at HMS and each of the participating institutions.