Pre & Post-Doctoral Training in Nephrology & Hypertension

描述（由申请人提供）： 学术肾病学家仍然迫切需要研究肾脏疾病的病因，发病机制和管理。高血压和糖尿病引起的肾病在全世界继续以惊人的速度增加;然而进入该领域进行研究的人数仍然不足。该培训补助金更新的目的是提供肾脏疾病，高血压和肾移植领域的基础，转化或临床研究方面的一流培训。培训将提供给博士前（2名博士或MD-博士生）和博士后（3名MD或博士）研究员，为期2至3年。每个受训人员将进行研究，并参加教学讲座。各种各样的研究领域可供研究，包括慢性肾脏疾病，高血压，糖尿病肾病，肾小球肾炎，移植，酸碱和电解质转运，临床研究（结果，药物基因组学和代谢驱动），以及基础科学（分子生物学，细胞信号传导或遗传学）。每个学员将有一个肾脏导师，一个非肾脏（基础科学或临床研究者）导师，和一个核心导师组。对于那些谁进入临床研究的公共卫生或MS在临床调查的学校MPH也可以获得。通过他们的培训完成所有申请人将提交他们的研究总结他们的核心导师组，给肾大轮，并准备一个赠款申请，由培训教师仔细评估未来的资金。这是我们的信念，一个有组织的，重点突出的计划，提供培训的基础到临床研究在肾脏病的全方位将提供一个有吸引力的场所招聘有前途的个人进入一个富有成效的学术生涯。本案无关肥胖、代谢综合征和糖尿病流行的主要后果是患有肾病的患者数量急剧增加。目前，有超过1000万人患有不同程度的肾功能不全，其中近80万人患有终末期或近终末期肾病。然而，进入调查职业的学术肾病学家严重短缺。该培训补助金将支持一个重点项目，用于培训有前途的候选人进行基础，转化和临床研究，这将帮助他们为肾脏病学的学术生涯做好准备。

DESCRIPTION (provided by applicant): There remains a critical need for academic nephrologists to investigate the etiologies, pathogenesis, and management of kidney diseases. Kidney disease from hypertension and diabetes continue to increase at an alarming rate throughout the world; yet the number of individuals entering the field to conduct research continues to be inadequate. The objective of this training grant renewal is to provide superb training in basic, translational, or clinical research in the field of kidney diseases, hypertension, and renal transplantation. Training will be provided to both predoctoral (2 PhD or MD-PhD students) and postdoctoral (3 MDs or PhDs) fellows, for 2 to 3 years. Each trainee will conduct research and also attend didactic lectures. A large variety of research areas are available for study, including chronic kidney disease, hypertension, diabetic renal disease, glomerulonephritis, transplantation, acid-base and electrolyte transport, clinical investigation (outcomes, pharmacogenomics, and investigator-driven), as well as in basic sciences (molecular biology, cell signaling, or genetics). Trainees will each have a renal mentor, a nonrenal (basic science or clinical investigator) mentor, and a core mentor group. For those who enter clinical research an MPH in the School of Public Health or MS in Clinical Investigation can also be obtained. By the completion of their training all applicants will submit a summary of their research to their core mentor group, give Renal Grand Rounds, and prepare a grant application for future funding that is carefully evaluated by the training faculty. It is our belief that an organized, well focused program that offers training across the full spectrum of basic to clinical research in nephrology will provide an attractive venue for the recruitment of promising individuals into a productive academic career. Relevance. A major consequence of the epidemic of obesity, metabolic syndrome, and diabetes has been a dramatic increase in the number of patients suffering from kidney disease. Currently there are over 10 million individuals with variable degrees of renal dysfunction, including nearly 800,000 with either end stage or near end stage renal disease. Yet, there is a critical shortage of academic nephrologists entering investigative careers. This training grant will support a focused program for training promising candidates in basic, translational, and clinical research which should help them prepare for an academic career in nephrology.