Multi-modal optical imaging applied to robot-assisted endoscopy (MOIRE)

在过去的15年里，光与组织的强烈而复杂的相互作用已经开始在临床应用中用于疾病诊断。吸收、散射、反射和荧光特性可以提供实时信号，以揭示与癌前病变发展相关的上皮和间质中的代谢和形态变化。通过多模式和多光谱成像的诊断特异性的潜在增加可以减少不必要的活检的数量并减少干预的延迟，改善当前缓慢且低效的白色光筛查程序。在同一时期，通过广泛使用微创手术（MIS）技术和开发复杂的人工控制手术机器人，手术技术也发生了革命，这些手术机器人允许执行手术环境限制所禁止的程序。目前，这些手术的手术导航基于从常规或立体内窥镜获取的白色光反射视频图像，给出仅报告组织颜色、形状和纹理的组织的有限视图。该项目的目的是开发一种多模态光学可视化技术，允许在原位，在手术领域的复杂解剖和功能信息的体内成像，并将其集成到机器人辅助手术中，以实现更安全，更有效的手术导航和诊断。

Over the past fifteen years the strong and complex interaction of light and tissue has begun to be exploited in clinical applications for the diagnosis of disease. The absorption, scattering, reflection and fluorescence properties can provide a live signal to reveal metabolic and morphologic changes in the epithelium and stroma associated with the development of pre-cancer. The potential increase in diagnostic specificity through multi-modal and multi-spectral imaging may reduce the number of unnecessary biopsies and reduce the delay to intervention, improving the current slow and inefficient white light screening procedures. During the same time period, there has also been a revolution in surgical technology through the widespread use of minimally invasive surgical (MIS) techniques and the development of sophisticated human-controlled surgical robots, which allow the performance of procedures that are otherwise prohibited by the confines of the operating environment. Currently, the surgical navigation for these procedures is based on white light reflected video images acquired from conventional or stereoscopic endoscopes, giving a limited view of the tissue that only reports tissue colour, shape and texture. The purpose of this project is to develop a multimodal optical visualisation technique that permits in situ, in vivo imaging of complex anatomical and functional information of the operating field and integrate this into robot assisted surgery for safer and more effective surgical navigation and diagnosis.