Synthetic Applications of Catalytic Ruthenium Complexes

惠特尔西和威廉姆斯小组之前的研究已经确定了非常活跃的催化剂，用于氢气加成和脱氢反应。这些催化剂将用于开发包括加氢和脱氢在内的新反应，以制备有用的有机产品。特别是，醇类的氧化不需要正式的氧化剂，为使用传统的氧化剂提供了一种环保的替代方案。该化学还将用于合成酰胺的新方法，酰胺广泛存在于天然产品和药物化合物中。Ru络合物的高反应性将被用于将含有硝基和丁腈的化合物转化为胺。由于含有硝基和腈的化合物在C-C成键反应中是有用的，这为合成广泛的胺类化合物提供了强有力的方法。借用氢化学的原理将被发展到杂环和复杂生物碱的合成，并扩展到手性控制的化合物的形成

Previous research from the Whittlesey and Williams groups has identified very active catalysts for reactions involving hydrogen addition and hydrogen removal. These catalysts will be used for the development of new reactions involving hydrogen addition and hydrogen removal to prepare useful organic products. In particular, the oxidation of alcohols without the need for a formal oxidant provides an environmentally-friendly alternative to the use of conventional oxidising agents. The chemistry will also be used for a new approach to the synthesis of amides, which are widely found in natural products and pharmaceutical compounds.The high reactivity of the ruthenium complexes will be exploited in the conversion of nitro and nitrile containing compounds into amines. Since nitro and nitrile containing compounds are useful in C-C bond forming reactions, this provides powerful methodology for the synthesis of a wide range of amines.The principles of the borrowing hydrogen chemistry will be developed for the synthesis of heterocycles and complex alkaloids, and extended to the formation of compounds with the control of chirality