SCORE Program at New Mexico State University, Las Cruces

描述(由申请人提供)：这是一份申请拉斯克鲁塞斯新墨西哥州立大学(NMSU)继续计分计划的申请书。NMSU的一个目标是扩大该机构的研究，让希望从事生物医学科学学科职业的少数民族学生参与其中。拟议的SCORE计划的目标是：(I)在未来四年内，将本申请中常规SCORE子项目的74%的调查人员过渡到竞争NIH的R01资金。(Ii)在今后四年内，将第二轮资助的SCORE分项目所有调查人员的发表记录提高到每年至少增加33%的研究手稿，发表在同行评议的推荐性期刊上。(3)通过开发核心研究设施，显著提高国家医疗服务大学进行生物医学相关研究的能力。(4)提高NMSU自我评估、评估和监督Score计划的能力，以实现机构自学、计划审查、支持更多计划任务以及内部研究管理改进的目的。 本申请书包含19个研究子项目和3个试验子项目的研究建议。这些建议中代表的学科包括农学、动物科学、生物化学、生物学、化学、分子生物学、微生物学和心理学。拟议项目的研究课题包括：动物细胞有丝分裂和胞质分裂、内耳发育过程中的感觉器官发生、生长激素轴和瘦素的基因组相互作用、共生弧菌的致病性、电鱼肌肉细胞中的转录因子、丙型肝炎病毒的翻译控制、鸽子和大鼠对低氧的适应、病原体的传播、微小隐孢子虫、金黄色葡萄球菌的杀菌耐受性、谷氨酰胺合成酶的调节、RNAi研究的细胞程序性死亡、生物大分子的电气和机械特性、生物医学应用的金属离子螯合剂、作为非血红素铁蛋白模型的高价铁化合物、放射性药物的化学合成、次级代谢的转录调控、生物医学应用的金属离子螯合剂。有机合成新的杂环和芳香化合物，植物耐旱耐盐转录图谱，粘土选择性结合对映体，以及通过皮质醇和行为同步性衡量婴儿学习。该计分计划将继续一个为期29年的MBRS计划，自1974年以来，该计划已使351名少数族裔学生(约占理科毕业生的81%)进入学士学位后培训，其中72人获得博士学位。

DESCRIPTION (provided by applicant): This is an application for a continuing SCORE Program at New Mexico State University (NMSU), Las Cruces. A goal of NMSU is to expand research at the institution for participation by ethnic minority students who desire to pursue careers in the biomedical science disciplines. The proposed SCORE Program has as its goals: (i) To transition, within the next four years, 74% of the investigators of regular SCORE subprojects in this application to competition for R01 funding from NIH. (ii) To enhance within the next four years, the publication records of all investigators of SCORE subprojects, who are in their second cycle of funding, to a minimum of 33% more research manuscripts per year in peer-reviewed, refereed journals. (iii) To significantly improve the capabilities of NMSU to conduct biomedically-relevant research through development of core research facilities. (iv) To improve the capacity of NMSU to self-evaluate, assess, and monitor the SCORE Program for the purpose of institutional self-study, program review, support of MORE Program missions, and internal improvement of research management. This application contains research proposals for nineteen research subprojects and three pilot subprojects. Disciplines represented among these proposals include Agronomy, Animal Science, Biochemistry, Biology, Chemistry, Molecular Biology, Microbiology and Psychology. The research topics of proposed projects include: mitosis and cytokinesis in animal cells, sensory organogenesis during inner ear development, genomic interactions of the growth hormone axis and leptin, pathogenicity in symbiotic vibrios, transcription factors in myogenic cells of electric fish, translational control of hepatitis C virus, adaptations of pigeons and rats to hypoxia, transmission of the pathogen, Cryptosporidium parvum, bacteriocide tolerance of Staphylococcus aureus, regulation of glutamine synthetase, programmed cell death studied by RNAi, electric and mechanical properties of bio-macromolecules, metal ion chelators for biomedical applications, high-valence iron complexes as models for non-heme iron proteins, chemical synthesis of radiopharmaceuticals, transcription regulation of secondary metabolism, organic synthesis of novel heterocyclic and aromatic compounds, transcriptional profiling of drought and salt tolerance in plants, selective binding of enantiomers by clays, and infant learning gauged by cortisol and behavioral synchrony. This SCORE Program will continue a 29-year MBRS Program which has advanced 351 minority students (approximately 81% of B.S.-graduated participants) to post-baccalaureate training, 72 earning Ph.D. degrees, since 1974.