SCORE Program at New Mexico State University, Las Cruces

新墨西哥州立大学拉斯克鲁塞斯分校 SCORE 项目

• 批准号: 6964141
• 负责人: GLENN D KUEHN
• 金额: $ 33.71万
• 依托单位: NEW MEXICO STATE UNIVERSITY LAS CRUCES
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-03-01 至 2008-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6964141
• 关键词: SCORE; Program; New; Mexico; State

DESCRIPTION (provided by applicant): This is an application for supplemental funding for a SCORE Program at New Mexico State University (NMSU) at Las Cruces. A goal of NMSU is to expand research at the institution for participation by ethnic minority students who desire to pursue careers in the biomedical science disciplines. The proposed SCORE Program has as its goals: (1) To significantly improve the capabilities of NMSU to conduct biomedically relevant research by increasing the numbers of faculty who conduct biomedical research, increasing the numbers of trained research personnel, increasing the inventory of specialized single-user research instrumentation, and improving the capacity to maintain research instrumentation; (2) To significantly improve the quantity and quality of biomedical research conducted at NMSU by broadening grantsmanship efforts of faculty participants and increasing the numbers and quality of research publications; (3) To integrate the activities of the SCORE Program with an anticipated RISE Program to maximize resources for training minority scientists in the biomedical sciences by engaging students in SCORE Program research projects; (4) To increase the capacity of NMSU to self-evaluate, assess, and monitor its multi-component research programs by engaging trained personnel in the SCORE Program's evaluation plan and subjecting the Program to annual review by an external evaluation committee. This application contains research proposals for four research subprojects and two pilot subprojects. Disciplines represented among the project proposals are diverse. They include bioinorganic chemistry (Smith), physical/synthetic organic chemistry (Starnes), neuro-cognitive psychology (Kroger), whole-animal endocrinology (Hawkins), modern cell biology (Curtiss), and pathogenic microbiology (Oshima). Specific areas proposed for investigation include: fMRI and EEC imaging methodologies to investigate the distribution of dynamic functions across the frontal cortex of the brain; applications of immunofluorescent probes and confocal microscopy to identify and assign functionality to new genes for head and eye patterning in Drosophila; development of porphyrin-based receptor molecules for the selective recognition of nitrite anion and other biologically relevant anions that can be used as biosensors; synthesis of model iron oxo-complexes that mimic enzyme-catalyzed reaction intermediates of nonheme dioxygenases; investigations of the ecology and transmission of the pathogen, Cryptosporidium parvum that will lead to the development of various Cryptosporidium diagnostic tools at species, genotype, and subgenotype levels; and studies of the role of polyamines, putrescine, spermidine, and spermine, produced by the agmatine pathway in the functions of the corpus luteum. NMSU has an existing SCORE Program which was initiated on June 1, 2000, and renewed on June 1, 2004. This Program currently funds eleven regular subprojects and no pilot subprojects. The existing SCORE Program succeeded a 25-year-old associate MBRS Program which produced 71 minority Ph.D. scientists in the period from 1974-2004.

描述(由申请人提供)：这是一份为拉斯克鲁塞斯的新墨西哥州立大学(NMSU)的SCORE项目申请补充资金的申请。NMSU的一个目标是扩大该机构的研究，让希望从事生物医学科学学科职业的少数民族学生参与其中。拟议的SCORE计划的目标是：(1)通过增加进行生物医学研究的教员人数，增加训练有素的研究人员的数量，增加专门的单用户研究仪器的库存，以及提高维护研究仪器的能力，显著提高NMSU进行生物医学相关研究的能力；(2)通过扩大教员参与人员的资助努力，增加研究出版物的数量和质量，显著提高NMSU进行的生物医学研究的数量和质量；(3)将Score计划的活动与预期的Rise计划相结合，通过让学生参与Score计划的研究项目，最大限度地利用资源培训生物医学领域的少数族裔科学家；(4)通过让训练有素的人员参与Score计划的评估计划，并由外部评估委员会对该计划进行年度审查，提高NMSU自我评估、评估和监测其多组成部分研究计划的能力。 本申请包含四个研究子项目和两个试验子项目的研究建议。在项目提案中代表的学科是不同的。它们包括生物无机化学(Smith)、物理/合成有机化学(Starnes)、神经认知心理学(Kroger)、全动物内分泌学(Hawkins)、现代细胞生物学(Curtiss)和病原微生物学(Oshima)。建议研究的具体领域包括：功能磁共振成像和EEC成像方法，以研究大脑额叶皮质的动态功能分布；免疫荧光探针和共聚焦显微镜的应用，以识别和分配果蝇头部和眼睛模式的新基因的功能；基于卟啉的受体分子的开发，用于选择性识别亚硝酸盐阴离子和其他可用作生物传感器的生物相关阴离子；模拟非血红素双加氧酶的酶催化反应中间体的模型铁氧络合物的合成；病原体微小隐孢子虫的生态和传播调查，这将导致在物种、基因和亚型水平上开发各种隐孢子虫诊断工具；以及研究由胍丁胺途径产生的多胺、腐胺、亚精胺和精胺在黄体功能中的作用。 NMSU现有的SCORE计划于2000年6月1日启动，并于2004年6月1日更新。该方案目前资助11个常规子项目，没有试验性子项目。现有的SCORE计划继承了已有25年历史的副MBRS计划，该计划在1974年至2004年期间培养了71名少数民族博士科学家。