An Experimental Model of Human Language and Cognition in Drug Dependence

描述（由申请人提供）：这个K23指导病人为导向的职业发展奖申请的候选人，肯尼思M。卡彭特博士，请求支持一项为期5年的培训和研究计划，旨在发展行为药理学实验方法和人类语言行为分析方面的专业知识，以调查人类语言行为和认知如何影响个人改变其习惯性使用药物的尝试。Vebal/认知过程在大多数人类活动中普遍存在，并且可以改变直接学习程序的效果。然而，很少有研究通过实验模拟人类语言和认知影响物质使用和行为变化的过程。人类语言和认知行为分析的令人兴奋的新发展为在受控实验室条件下直接研究言语/认知过程提供了理论基础和实验框架。该提案将为Carpenter博士提供必要的培训，以开发一个实验平台，用于模拟与药物使用相关的言语/认知过程，并将这些模型转化为临床环境，以研究药物治疗期间的言语/认知变化机制。Carpenter博士提出了职业发展活动，这些活动建立在他的临床心理学和研究背景之上，并利用哥伦比亚大学和纽约州立精神病学研究所的资源，以促进他成为独立临床研究者的长期目标。作为一个全面的教育计划的一部分，卡彭特博士将在研究的道德行为，设计和进行实验，结合联合收割机人类行为药理学和言语行为研究方法，在心理语言学和心理治疗过程研究指导，并授予写作和管理密集的指导。短期目标是获得适应和测试人类实验室自我管理范式中的人类言语/认知实验模型的技能，并在临床背景下采用该模型来预测参加CBT干预的可卡因依赖患者的治疗结果。与公共卫生的相关性：可卡因的使用在美国相当普遍，并与严重的心理社会问题有关。确定促进行为改变的因素可以改善我们的预防和干预工作，并对公共卫生产生积极影响。

DESCRIPTION (provided by applicant): The candidate of this K23 Mentored Patient-Oriented Career Development Award application, Kenneth M. Carpenter, Ph.D., requests support for a 5-year program of training and research aimed at developing expertise in the experimental methodologies of behavioral pharmacology and the analysis of human verbal behavior in order to investigate the processes by which human verbal behavior and cognition can affect individuals' attempts to change their habitual use of drugs. Vebal/Cognitive processes are pervasive in most human activities and can alter the effects of direct learning procedures. However, few studies have experimentally modeled the processes by which human language and cognition influence substance use and behavioral change. Exciting new developments in the behavioral analysis of human language and cognition offer a theoretical basis and experimental framework for directly investigating verbal/cognitive processes under controlled laboratory conditions. This proposal will provide Dr. Carpenter with the necessary training to develop an experimental platform for modeling the verbal/cognitive processes associated with drug use and translate these models to the clinical context to investigate verbal/cognitive mechanisms of change during drug treatment. Dr. Carpenter proposes career development activities that build on his background in clinical psychology and research and capitalize on the resources of Columbia University and New York State Psychiatric Institute to promote his long-term goal of becoming an independent clinical investigator. As part of a comprehensive educational plan, Dr. Carpenter will receive intensive mentoring in the ethical conduct of research, designing and conducting experiments that combine human behavioral pharmacology and the analysis of verbal behavior research methods, instruction in psycholinguistics and psychotherapy process research, and grant writing and management. The short-term goals are to acquire the skills to adapt and test an experimental model of human verbal/cognition in a human laboratory self-administration paradigm and employ this model in a clinical context to predict treatment outcome among cocaine dependent patients enrolled in a CBT intervention. Relevance to Public Health: Cocaine use is fairly prevalent in the US and is associated with significant psychosocial problems. Identifying factors that promote behavioral change can improve our prevention and intervention efforts and have a positive impact on public health.