Improving Mealtime Functioning in Families of Young Children with Type 1 Diabetes

描述(由申请人提供)： 这位K23候选人是密歇根大学儿科系的儿科心理学家和初级教员。她最近完成了一项关于1型糖尿病(T1 DM)幼儿就餐行为研究的NRSA奖学金，现在需要一个高度专业化的教学和高级指导的最终计划，才能成为联邦政府资助的儿童糖尿病临床研究的领先者。 候选人的长期职业目标是率先开发有效的新行为干预措施，以改善患有T1 DM的幼儿的亲子功能、生活质量和健康结果。她近期的职业发展目标是：1)完成临床研究培训，2)加深她在幼儿T1 DM和相关健康结果测量方面的专业知识，3)成为联邦政府资助的儿科糖尿病临床研究的领先者。 因此，候选人提出了一个为期五年的计划，由全国知名的临床研究人员进行密集的指导和培训；结构化的教学学，涵盖行为医学中的临床干预措施的开发，随机临床试验的设计，拨款撰写技能和研究伦理；以及一个两项研究的研究计划。研究一将使用一项针对32名儿童及其家庭的前瞻性行为观察研究，以检验围绕亲子就餐行为、父母心理因素和儿童血糖控制的一系列假设。在研究2期间，研究1的结果将推动一种新的行为干预的规范，以改善用餐时间的功能。在经过反复的发育试验和专家评审后，候选人将通过对10名儿童及其家庭的初步研究来评估由此产生的标准化干预对血糖的影响。 总之，拟议的活动计划是候选人发展成为完全独立的、以患者为中心的儿科糖尿病研究人员所需的最后步骤。这位候选人的成功可能会对公共卫生产生重大影响，因为T1 DM是幼儿中的常见病，而有效干预措施的设计可以改善大约22,000名美国儿童和家庭的功能和健康结果。

DESCRIPTION (provided by applicant): The K23 candidate is a pediatric psychologist and junior faculty member in the Department of Pediatrics at the University of Michigan. She recently completed an NRSA fellowship in the study of mealtime behaviors in young children with type 1 diabetes (T1DM), and now requires a final program of highly specialized didactics and advanced mentorship in order to become a leading federally-funded clinical investigator in pediatric diabetes. The candidate's long term career goal is to pioneer the development of effective new behavioral interventions to improve parent-child functioning, quality of life, and health outcomes in young children with T1DM. Her immediate career development goals are to: 1) complete her training in clinical research, 2) deepen her expertise on T1DM in young children and the measurement of related health outcomes, and 3) become a leading federally-funded clinical investigator in pediatric diabetes. The candidate thus proposes a five-year program of intensive mentorship and training by nationally renowned clinical investigators; structured didactics covering the development of manualized clinical interventions in behavioral medicine, the design of randomized clinical trials, grant writing skills, and research ethics; and a two-Study research plan. Study 1 will use a prospective behavioral observation study of 32 children and their families to test a set of hypotheses surrounding parent-child mealtime behaviors, parent psychological factors, and children's blood glucose control. During Study 2, the results of Study 1 will drive the specification of a new behavioral intervention to improve mealtime functioning. After an iterative program of developmental trials and expert review, the candidate will estimate the blood glucose impact of the resulting standardized intervention through a pilot study of 10 children and their families. To summarize, the proposed program of activities are the final steps needed for the candidate to develop into a fully independent patient-oriented investigator in pediatric diabetes. The candidate's success potentially has major public health impact, because T1DM is a common disease among young children, and the design of effective interventions could improve functioning and health outcomes for approximately 22,000 US children and families.