Photoreceptor Function in Retinopathy of Prematurity

活动性早产儿视网膜病变（ROP），这是已知的视网膜缺氧的反应，发生在 视杆细胞外节快速发育的年龄。研究人员假设，快速增加氧气 发育中的视杆细胞的需求导致缺氧，从而引发ROP， 如果代谢需求得不到满足，视杆细胞功能就会受损。虽然承认“光感受器假说” ROP”将不会被直接测试，光感受器和ROP的发展的知识创造了 项目的框架。已完成的ROP受试者在足月后年龄的研究记录了以下证据 损坏的棒。在新项目的目标1中，将在早产年龄测量视杆细胞敏感性Srod 在此期间ROP通常是活动的。这是重要的，因为示范杆参与积极的 ROP将保证ROP管理的新视角，其原则将是： 光感受器的需求。将对早产儿视网膜血管进行数值分析。Srod和 将分析血管参数以预测ROP结果、高风险预处理的可能性， 阈值ROP和视网膜和视觉功能的后期发育。在健康ROP受试者中，轻度 视敏度缺陷可能是神经血管改变残留的轻微黄斑病变的常见征象。 中心凹和中心凹无血管区的发育。在目标2中，将评价中央视网膜功能 （包括ROP婴儿的多焦ERG），并在儿童早期进行跟踪。迄今为止的结果表明， 视杆细胞功能障碍和早期屈光不正之间存在关联，但关于视网膜功能障碍的研究仍有待进一步发现。 这是ROP儿童中很大一部分发生早期屈光不正的机制。因此 目标3的实验将更新屈光测量并分析儿童ROP的视网膜机制 研究对象以前在婴儿期就被研究过。对于每组实验，交叉分析 截面数据将评估视网膜和视觉参数随ROP结果的显著变化。的 将评价纵向数据随时间的变化和ROP结果的变化。该项目将 获得有关基本疾病过程的新知识，有助于理解屈光 ROP的发展，并提供了新的见解的基础上常见的敏锐度缺陷。这些信息 在未来，可能会改变婴儿期和有ROP病史的儿童的ROP管理。

Active retinopathy of prematurity (ROP), which is known to be a response to retinal hypoxia, occurs at the age of rapid rod outer segment development. The investigators postulate that rapidly increasing oxygen demands of the developing rods contribute to the hypoxia that instigates ROP, and, as a consequence of unmet metabolic needs, rod function is impaired. While acknowledging that the "photoreceptor hypothesis of ROP" will not be put to direct test, knowledge of the development of the photoreceptors and of ROP creates a framework for the project. Completed studies in ROP subjects at post-term ages document evidence of damaged rods. In Aim 1 of the new project, rod cell sensitivity, Srod, will be measured at pre-term ages during which ROP is typically active. This is important because demonstration of rod involvement in active ROP will warrant a new perspective on ROP management, the principle of which will be: Satisfy oxygen needs of photoreceptors. A numeric analysis of preterm retinal blood vessels will be conducted. Srod and blood vessel parameters will be analyzed for prediction of ROP outcome, the probability of high risk pre- threshold ROP, and post-term development of retinal and visual function. In healthy ROP subjects, mild acuity deficits may be the common sign of a subtle maculopathy as residua of altered neural-vascular development of fovea and foveal avascular zone. In Aim 2, central retinal function will be evaluated (including multifocal ERG in ROP infants) and tracked through early childhood. Results to date demonstrate an association of rod dysfunction and early ametropia, but more remains to be discovered about retinal mechanisms in that substantial proportion of ROP children who develop early ametropia. Accordingly, the experiments of Aim 3 will update refractive measurements and analyze retinal mechanisms in child ROP subjects who were previously studied in infancy. For each set of experiments, the analyses of the cross sectional data will evaluate the retinal and visual parameters for significant variation with ROP outcome. The longitudinal data will be evaluated for change over time and for variation with ROP outcome. The project will obtain new knowledge about the fundamental disease process, contribute to the understanding of refractive development in ROP, and provide new insights into the basis of common acuity deficits. This information may, in the future, change management of ROP in infancy and in children with a history of ROP.