New Orleans Adolescent Medicine Trials Unit

新奥尔良青少年医学试验单位（ATU）是一个拟议的（和目前的）合作临床 艾滋病毒/艾滋病干预青少年医学试验网络（ATN）的活动， 研究工作。ATN的主要使命是进行研究，无论是独立的， 与其他现有的研究网络和调查人员合作，在青春期前、青少年和 感染艾滋病毒或有感染艾滋病毒风险的年轻人。这项研究的公共卫生目标 努力支持通过初级教育， 二级和三级预防。研究结果将有助于个人和社区了解 艾滋病毒预防战略对受艾滋病毒影响最严重的年轻人来说是可以接受和有效的。 新奥尔良ATU计划通过继续开发 《Connect to Protect：New Orleans》（C2P）C2 P：新奥尔良正在开发一个基于社区的 基础设施，以支持临床试验评估行为，疫苗和其他生物医学模式定制 新奥尔良的年轻人，特别是非洲裔美国年轻人， 妇女计划包括评估这一过程，翻译有效的行为方案，在这一过程中， 社区，对社区进行临床试验教育的方式， 生物医学的进步，如疫苗和杀微生物剂。 计划进行二级预防研究，以保护感染艾滋病毒的青年的健康和功能。 研究包括：管理策略，如短周期抗逆转录病毒治疗和HBV的评估 免疫接种计划;关键领域的调查，如生长期间治疗的长期影响 和成熟，免疫特异性HIV发病机制，以及疫苗影响下的免疫恢复 和基于免疫的疗法;解决艾滋病毒引起的恶性肿瘤等并发症的策略;以及 促进坚持医学治疗和预防艾滋病毒传染给他人的战略。 三级预防研究的目的是改善临床管理的青年谁目前非常生病 或者几乎没有剩余的治疗选择。每项研究都需要其独特的方法，所有研究都将 需要跨学科合作，以解决艾滋病毒感染和高危人群的复杂性。

The New Orleans Adolescent Medicine Trials Unit (ATU) is a proposed (and current) collaborating clinical site for.the activites of the Adolescent Medicine Trials Network for HIV/AIDS Interventions (ATN), a national research effort. The primary mission of the ATN is to conduct research, both independently and in collaboration with other existing research networks and investigators, in pre-adolescents, adolescents and young adults who are HIV infected or are at risk for HIV infection. The public health goal of this research effort is to support limitation of the impact and spread of HIV among young people through primary, secondary, and tertiary prevention. Research results will serve to inform individuals and communities about HIV prevention strategies that are acceptable and effective for young people most affected by HIV. The New Orleans ATU plans to continue primary prevention research through the continued development of Connect to Protect: New Orleans (C2P). C2P: New Orleans is developing a community-based infrastructure to support clinical trials evaluating behavioral, vaccine and other biomedical modalities tailored for New Orleans youth most at risk for HIV infection and transmission, particularly African-American young women. Plans include evaluation of this process, of translation of effective behavioral programs in this community, of ways of educating the community about clinical trials, of acceptability, use and effect of biomedical advances such as vaccines and microbicides. Secondary prevention studies are planned to preserve the health and functioning of HIV-infected youth. Studies include: management strategies such as short-cycle ARV therapy and evaluation of HBV immunization schedules; investigations of key areas such as long-term effects of therapies during growth and maturation, adolescent-specific HIV pathogenesis, and immune recovery under the influence of vaccine and immune-based therapies; strategies to address co-morbidities such as HIV-induced malignancies; and strategies to promote adherence to medical therapies and prevention of HIV transmission to others. Tertiary prevention studies are aimed at improving the clinical management of youth who present very ill or have few remaining therapeutic options. Each study will require its own unique methods, and all will require interdisciplinary collaborations to address the complexity of HIV infected and at-risk populations.