Monolithic integration of optical traps and microfluidic channels

该项目的主要动机是让生命科学界更容易获得光学捕获工具包。通过将光学陷阱直接集成到微流控电路中，我们将为单芯片实验室类型的设备添加功能，从而使它们离实际应用更近一步。我们将通过开发我们最近演示的集成光学陷阱的概念来实现这一目标。通过增加其功率输出和使用光束整形来增加光陷阱中的强度，从而能够控制大量不同类型的细胞，从而使陷阱变得更加通用。将开发一种光学层析设备，提供快速和简单的细胞群体分离，并具有集成的分离通道，这些通道是光学寻址的。实现其他波长的电路，即用于拉曼光谱的780 nm和用于荧光激发的635 nm以及410 nm，将进一步突出集成陷阱概念的潜力。

The key motivation for the project is to make the optical trapping toolkit more accessible to the life sciences community. By integrating optical traps directly into microfluidic circuitry, we will add functionality to Lab-on-a-chip type devices, thus taking them a step closer to real applications. We will reach this aim by developing the concept of an integrated optical trap that we have demonstrated recently. The trap will be made more versatile by increasing its power output and by using beamshaping to increase the intensity in the optical trap, thus being able to control a large number of different cell types. An optical chromatography device that offers the fast and simple fractionation of a cell population will be developed, with integrated separation channels that are optically addressed. Realising circuits at other wavelengths, namely 780 nm for Raman spectroscopy and 635 as well as 410 nm for fluorescence excitation, will highlight the potential of the integrated trap concept further.