Ultra-stable, phase sensitive, snapshot OCT system enabled by 2-Photon additive manufacturing

通过 2 光子增材制造实现超稳定、相敏、快照 OCT 系统

• 批准号: 10607853
• 负责人: Brian E. Applegate
• 金额: $ 25.07万
• 依托单位: UNIVERSITY OF SOUTHERN CALIFORNIA
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-15 至 2025-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10607853
• 关键词: 3-Dimensional; 3D Print; Air; Angiography; Biological; Biomedical Research; Cardiology; Clinical; Collaborations; Collection; Complex; Custom; Data Set; Dermatology; Development; Devices; Endoscopes; Endoscopy; Event; Feasibility Studies; Funding; Gastroenterology; Goals; Image; Imaging Techniques; Iris; Lateral; Maps; Masks; Measurement; Methods; Modality; Monitor; Morphologic artifacts; Motion; Multimodal Imaging; Ophthalmology; Optical Coherence Tomography; Optics; Performance; Phase; Plant Resins; Polymers; Positioning Attribute; Predisposition; Printing; Process; Research; Resolution; Rice; Risk; Sampling; Scanning; Series; Source; Spectrum Analysis; Speed; Structure; System; Systems Integration; Techniques; Technology; Testing; Therapeutic; Three-Dimensional Imaging; Tissues; Validation; With laterality; Work; adaptive optics; analog; body cavity; clinical application; clinical diagnosis; cost; design; detector; digital; elastography; experimental study; fabrication; innovative technologies; instrument; interest; lens; manufacture; miniaturize; nanoscale; new technology; novel; polymerization; pre-clinical; programs; quantum; response; scale up; sensor; technology development; technology platform; technology research and development; two-photon; vibration

In this proposal we aim to build a platform technology for volumetric OCT snapshot imaging using principle of Image Mapping Spectroscopy. We will demonstrate Full Field Spectral Domain OCT ((FFSDOCT)) system in free space. The volumetric functional OCT will be enabled by leveraging advanced 2Photon Polymerization 3-D printing approaches, that will permit printing of arbitrary optical quality structures. To achieve these goals, we will utilize state of the art Quantum X system from Nanoscribe. The device allows the combination of small, and medium size detail allowing feature sizes down to 140 nm. The roughness obtained in the printing process is below 20 nm. Prints will be performed in clear resins (IV-Dip, SU8 analogs etc.). It also permits unprecedented print volumes in comparison to other 2PP printers. Specifically, the proof of concept Full Field Spectral Domain OCT will use custom designed 3-D printed multifaceted mirror imaged and dispersed onto a 2-D sCMOS sensor. The mapping mirror will incorporate 10,000 miniature facets and 100 unique tilts to map 100x100 image points onto a camera sensor. In result the system will operate as an array of parallel, high resolution spectrometers where the number of spectrometers equals the number of object points. The resulting FFSDOCT system will have no moving parts yet be capable of acquiring volumetric OCT images at the frame rate of the sensor (30 Hz). The imaging spectrometer will linearly sample in wavenumber. To evaluate system, we will perform series of imaging experiments in free space. FFSDOCT will be characterized for resolution, system sensitivity, the measurement of flow and nanoscale vibrations.

在本提案中，我们的目标是利用以下原理构建体积 OCT 快照成像平台技术： 图像映射光谱。我们将免费演示全场谱域 OCT ((FFSDOCT)) 系统 空间。体积功能 OCT 将通过利用先进的 2Photon 聚合 3-D 来实现 印刷方法，将允许印刷任意光学质量结构。为了实现这些目标，我们 将利用 Nanoscribe 最先进的 Quantum X 系统。该设备允许组合小型和 中等尺寸细节，允许特征尺寸小至 140 nm。印刷过程中获得的粗糙度为 20纳米以下。打印将在透明树脂（IV-Dip、SU8 类似物等）中进行。这也使得前所未有的 与其他 2PP 打印机相比的打印量。 具体来说，概念验证全场谱域 OCT 将使用定制设计的 3D 打印 多面镜面成像并分散到二维 sCMOS 传感器上。映射镜将包含 10,000 个微型面和 100 个独特的倾斜，可将 100x100 图像点映射到相机传感器上。结果是 系统将作为并行、高分辨率光谱仪阵列运行，其中光谱仪的数量 等于对象点的数量。由此产生的 FFSDOCT 系统将没有移动部件，但能够 以传感器的帧速率 (30 Hz) 获取体积 OCT 图像。成像光谱仪将线性 波数中的样本。 为了评估系统，我们将在自由空间中进行一系列成像实验。 FFSDOCT 将被表征 用于分辨率、系统灵敏度、流量和纳米级振动的测量。