Ultra-stable, phase sensitive, snapshot OCT system enabled by 2-Photon additive manufacturing
通过 2 光子增材制造实现超稳定、相敏、快照 OCT 系统
基本信息
- 批准号:10607853
- 负责人:
- 金额:$ 25.07万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2023
- 资助国家:美国
- 起止时间:2023-09-15 至 2025-08-31
- 项目状态:未结题
- 来源:
- 关键词:3-Dimensional3D PrintAirAngiographyBiologicalBiomedical ResearchCardiologyClinicalCollaborationsCollectionComplexCustomData SetDermatologyDevelopmentDevicesEndoscopesEndoscopyEventFeasibility StudiesFundingGastroenterologyGoalsImageImaging TechniquesIrisLateralMapsMasksMeasurementMethodsModalityMonitorMorphologic artifactsMotionMultimodal ImagingOphthalmologyOptical Coherence TomographyOpticsPerformancePhasePlant ResinsPolymersPositioning AttributePredispositionPrintingProcessResearchResolutionRiceRiskSamplingScanningSeriesSourceSpectrum AnalysisSpeedStructureSystemSystems IntegrationTechniquesTechnologyTestingTherapeuticThree-Dimensional ImagingTissuesValidationWith lateralityWorkadaptive opticsanalogbody cavityclinical applicationclinical diagnosiscostdesigndetectordigitalelastographyexperimental studyfabricationinnovative technologiesinstrumentinterestlensmanufactureminiaturizenanoscalenew technologynovelpolymerizationpre-clinicalprogramsquantumresponsescale upsensortechnology developmenttechnology platformtechnology research and developmenttwo-photonvibration
项目摘要
In this proposal we aim to build a platform technology for volumetric OCT snapshot imaging using principle of
Image Mapping Spectroscopy. We will demonstrate Full Field Spectral Domain OCT ((FFSDOCT)) system in free
space. The volumetric functional OCT will be enabled by leveraging advanced 2Photon Polymerization 3-D
printing approaches, that will permit printing of arbitrary optical quality structures. To achieve these goals, we
will utilize state of the art Quantum X system from Nanoscribe. The device allows the combination of small, and
medium size detail allowing feature sizes down to 140 nm. The roughness obtained in the printing process is
below 20 nm. Prints will be performed in clear resins (IV-Dip, SU8 analogs etc.). It also permits unprecedented
print volumes in comparison to other 2PP printers.
Specifically, the proof of concept Full Field Spectral Domain OCT will use custom designed 3-D printed
multifaceted mirror imaged and dispersed onto a 2-D sCMOS sensor. The mapping mirror will incorporate
10,000 miniature facets and 100 unique tilts to map 100x100 image points onto a camera sensor. In result the
system will operate as an array of parallel, high resolution spectrometers where the number of spectrometers
equals the number of object points. The resulting FFSDOCT system will have no moving parts yet be capable of
acquiring volumetric OCT images at the frame rate of the sensor (30 Hz). The imaging spectrometer will linearly
sample in wavenumber.
To evaluate system, we will perform series of imaging experiments in free space. FFSDOCT will be characterized
for resolution, system sensitivity, the measurement of flow and nanoscale vibrations.
在本提案中,我们的目标是建立一个平台技术的体积OCT快照成像使用的原则,
图像映射光谱学。我们将免费演示全视场谱域OCT((FFSDOCT))系统
空间将通过利用先进的2 Photon Polymerization 3-D技术实现容积功能OCT
印刷方法,这将允许印刷任意光学质量的结构。为了实现这些目标,我们
将利用Nanoscribe的最先进的Quantum X系统。该设备允许结合小,
中等尺寸细节,允许特征尺寸低至140 nm。在印刷过程中获得的粗糙度是
低于20 nm。将在透明树脂(IV-Dip、SU 8类似物等)中进行打印。它还允许前所未有的
打印量与其他2 PP打印机相比。
具体而言,全视场谱域OCT概念验证将使用定制设计的3D打印
多面镜成像并分散到2-D sCMOS传感器上。映射镜将包含
10,000个微型刻面和100个独特的倾斜度,将100 x100个图像点映射到相机传感器上。结果,
系统将作为平行的高分辨率光谱仪阵列操作,其中光谱仪的数量
等于物点数。最终的FFSDOCT系统将没有移动部件,但能够
以传感器的帧速率(30 Hz)采集体积OCT图像。成像光谱仪将线性地
波数抽样
为了评估系统,我们将在自由空间进行一系列成像实验。将对FFSDOCT进行表征
分辨率、系统灵敏度、流量测量和纳米级振动。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Brian E. Applegate其他文献
Analysis of ear symmetry as a diagnostic tool enabled by optical coherence tomography
通过光学相干断层扫描分析耳朵对称性作为诊断工具
- DOI:
- 发表时间:
2024 - 期刊:
- 影响因子:0
- 作者:
Zihan Yang;Wihan Kim;Marcela A. Morán;Ryan Long;J. Oghalai;Brian E. Applegate - 通讯作者:
Brian E. Applegate
Visualizing motions within the cochlea's organ of Corti and illuminating cochlear mechanics with optical coherence tomography
- DOI:
10.1016/j.heares.2024.109154 - 发表时间:
2025-01-01 - 期刊:
- 影响因子:
- 作者:
Elizabeth S. Olson;Wei Dong;Brian E. Applegate;Karolina K. Charaziak;James B. Dewey;Brian L. Frost;Sebastiaan W.F. Meenderink;Jong-Hoon Nam;John S. Oghalai;Sunil Puria;Tianying Ren;C. Elliott Strimbu;Marcel van der Heijden - 通讯作者:
Marcel van der Heijden
Ex-vivo imaging of the human cochlea using 1.7μm SS-OCT
使用 1.7μm SS-OCT 对人类耳蜗进行离体成像
- DOI:
- 发表时间:
2024 - 期刊:
- 影响因子:0
- 作者:
Jack C. Tang;Dorothy W. Pan;J. Oghalai;Brian E. Applegate - 通讯作者:
Brian E. Applegate
Morphological and biochemical imaging of coronary atherosclerotic plaques using optical coherence tomography and fluorescence lifetime imaging
- DOI:
10.1016/j.carrev.2009.04.053 - 发表时间:
2009-07-01 - 期刊:
- 影响因子:
- 作者:
Javier A. Jo;Brian E. Applegate;Fred Clubb - 通讯作者:
Fred Clubb
Brian E. Applegate的其他文献
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{{ truncateString('Brian E. Applegate', 18)}}的其他基金
High-Speed, Low-Cost, Image Remapping Spectral Domain Full-Field Optical Coherence Tomography for Retinal Imaging
用于视网膜成像的高速、低成本图像重映射谱域全场光学相干断层扫描
- 批准号:
10670648 - 财政年份:2023
- 资助金额:
$ 25.07万 - 项目类别:
Comb Light Source/Imaging spectrometer for advanced Spectral Domain Optical Coherence Tomography
用于先进谱域光学相干断层扫描的梳状光源/成像光谱仪
- 批准号:
10058117 - 财政年份:2020
- 资助金额:
$ 25.07万 - 项目类别:
Comb Light Source/Imaging spectrometer for advanced Spectral Domain Optical Coherence Tomography
用于先进谱域光学相干断层扫描的梳状光源/成像光谱仪
- 批准号:
10242951 - 财政年份:2020
- 资助金额:
$ 25.07万 - 项目类别:
Optical imaging technologies to identify residual cholesteatoma and improve ossiculoplasty outcomes
光学成像技术可识别残余胆脂瘤并改善骨成形术结果
- 批准号:
9899243 - 财政年份:2019
- 资助金额:
$ 25.07万 - 项目类别:
Optical imaging technologies to identify residual cholesteatoma and improve ossiculoplasty outcomes
光学成像技术可识别残余胆脂瘤并改善骨成形术结果
- 批准号:
10373930 - 财政年份:2019
- 资助金额:
$ 25.07万 - 项目类别:
Morphological and Molecular Imaging System for in vivo Atherosclerosis Research
用于体内动脉粥样硬化研究的形态和分子成像系统
- 批准号:
8450783 - 财政年份:2012
- 资助金额:
$ 25.07万 - 项目类别:
Morphological and Molecular Imaging System for in vivo Atherosclerosis Research
用于体内动脉粥样硬化研究的形态和分子成像系统
- 批准号:
9039653 - 财政年份:2012
- 资助金额:
$ 25.07万 - 项目类别:
Morphological and Molecular Imaging System for in vivo Atherosclerosis Research
用于体内动脉粥样硬化研究的形态和分子成像系统
- 批准号:
8645722 - 财政年份:2012
- 资助金额:
$ 25.07万 - 项目类别:
Morphological and Molecular Imaging System for in vivo Atherosclerosis Research
用于体内动脉粥样硬化研究的形态和分子成像系统
- 批准号:
8222478 - 财政年份:2012
- 资助金额:
$ 25.07万 - 项目类别:
Development of high-resolution molecular imaging of endogenous chromophores with
内源性发色团高分辨率分子成像的发展
- 批准号:
7845631 - 财政年份:2009
- 资助金额:
$ 25.07万 - 项目类别:
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