Ultra-stable, phase sensitive, snapshot OCT system enabled by 2-Photon additive manufacturing

通过 2 光子增材制造实现超稳定、相敏、快照 OCT 系统

• 批准号: 10607853
• 负责人: Brian E. Applegate
• 金额: $ 25.07万
• 依托单位: UNIVERSITY OF SOUTHERN CALIFORNIA
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-15 至 2025-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10607853
• 关键词: 3-Dimensional; 3D Print; Air; Angiography; Biological; Biomedical Research; Cardiology; Clinical; Collaborations; Collection; Complex; Custom; Data Set; Dermatology; Development; Devices; Endoscopes; Endoscopy; Event; Feasibility Studies; Funding; Gastroenterology; Goals; Image; Imaging Techniques; Iris; Lateral; Maps; Masks; Measurement; Methods; Modality; Monitor; Morphologic artifacts; Motion; Multimodal Imaging; Ophthalmology; Optical Coherence Tomography; Optics; Performance; Phase; Plant Resins; Polymers; Positioning Attribute; Predisposition; Printing; Process; Research; Resolution; Rice; Risk; Sampling; Scanning; Series; Source; Spectrum Analysis; Speed; Structure; System; Systems Integration; Techniques; Technology; Testing; Therapeutic; Three-Dimensional Imaging; Tissues; Validation; With laterality; Work; adaptive optics; analog; body cavity; clinical application; clinical diagnosis; cost; design; detector; digital; elastography; experimental study; fabrication; innovative technologies; instrument; interest; lens; manufacture; miniaturize; nanoscale; new technology; novel; polymerization; pre-clinical; programs; quantum; response; scale up; sensor; technology development; technology platform; technology research and development; two-photon; vibration

In this proposal we aim to build a platform technology for volumetric OCT snapshot imaging using principle of Image Mapping Spectroscopy. We will demonstrate Full Field Spectral Domain OCT ((FFSDOCT)) system in free space. The volumetric functional OCT will be enabled by leveraging advanced 2Photon Polymerization 3-D printing approaches, that will permit printing of arbitrary optical quality structures. To achieve these goals, we will utilize state of the art Quantum X system from Nanoscribe. The device allows the combination of small, and medium size detail allowing feature sizes down to 140 nm. The roughness obtained in the printing process is below 20 nm. Prints will be performed in clear resins (IV-Dip, SU8 analogs etc.). It also permits unprecedented print volumes in comparison to other 2PP printers. Specifically, the proof of concept Full Field Spectral Domain OCT will use custom designed 3-D printed multifaceted mirror imaged and dispersed onto a 2-D sCMOS sensor. The mapping mirror will incorporate 10,000 miniature facets and 100 unique tilts to map 100x100 image points onto a camera sensor. In result the system will operate as an array of parallel, high resolution spectrometers where the number of spectrometers equals the number of object points. The resulting FFSDOCT system will have no moving parts yet be capable of acquiring volumetric OCT images at the frame rate of the sensor (30 Hz). The imaging spectrometer will linearly sample in wavenumber. To evaluate system, we will perform series of imaging experiments in free space. FFSDOCT will be characterized for resolution, system sensitivity, the measurement of flow and nanoscale vibrations.

在本提案中，我们的目标是建立一个平台技术的体积OCT快照成像使用的原则， 图像映射光谱学。我们将免费演示全视场谱域OCT（（FFSDOCT））系统 空间将通过利用先进的2 Photon Polymerization 3-D技术实现容积功能OCT 印刷方法，这将允许印刷任意光学质量的结构。为了实现这些目标，我们 将利用Nanoscribe的最先进的Quantum X系统。该设备允许结合小， 中等尺寸细节，允许特征尺寸低至140 nm。在印刷过程中获得的粗糙度是 低于20 nm。将在透明树脂（IV-Dip、SU 8类似物等）中进行打印。它还允许前所未有的 打印量与其他2 PP打印机相比。 具体而言，全视场谱域OCT概念验证将使用定制设计的3D打印 多面镜成像并分散到2-D sCMOS传感器上。映射镜将包含 10，000个微型刻面和100个独特的倾斜度，将100 x100个图像点映射到相机传感器上。结果， 系统将作为平行的高分辨率光谱仪阵列操作，其中光谱仪的数量 等于物点数。最终的FFSDOCT系统将没有移动部件，但能够 以传感器的帧速率（30 Hz）采集体积OCT图像。成像光谱仪将线性地 波数抽样 为了评估系统，我们将在自由空间进行一系列成像实验。将对FFSDOCT进行表征 分辨率、系统灵敏度、流量测量和纳米级振动。