SWAN Sleep Study II - Chicago (Rush) Site

中年女性的睡眠中断增加，部分原因是年龄本身的影响，但也 可能部分由于绝经过渡期，即激素、症状和出血的变化， 发生在更年期过渡期。目前，修订后的提案（睡眠II）将纵向延伸， 目前资助的，多地点，多种族的中年妇女睡眠横断面研究（睡眠I）。在睡梦中， 对370名中年绝经前、绝经后和绝经后的白人进行了基于年龄的检查， 非裔美国人和中国妇女来自妇女健康研究的七个研究地点中的四个 全国范围内（天鹅，更年期和衰老的纵向研究），使用家庭多导睡眠图， 每日日记和活动记录仪，以及自我报告的睡眠问卷。在Sleep II中，使用CoordinatedR 01 根据这一机制，将对同一批妇女进行第二次实地审查（她们将被 年龄51-62岁），采用相同的程序。一个被广泛引用的启发式模型， 睡眠障碍的病理生理学将应用于这些纵向数据，以评估 在这个多种族的女性样本中与更年期相关的睡眠障碍。该模型将急性 睡眠障碍的综合作用的诱发和促发因素，并持续 慢性睡眠障碍超出急性应激源的永久因素。 对绝经过渡期睡眠进行纵向评估的具体目的是 确定潜在因素：1）诱发因素（种族、社会经济地位低、体力活动水平低， 高体重指数、吸烟、睡眠问题史、健康状况差）; 2）诱发因素 （血管扩张症状、新的不良生活事件、促卵泡激素快速增加） 过渡期间的睡眠障碍; 3）永久性因素（睡眠卫生不良，功能失调的态度 和对睡眠的信念，夜间认知和生理唤醒的增强，种族） 过渡期间的干扰;和4）睡眠障碍对随后的健康状况的不利影响 在绝经后早期（代谢特征和生活质量恶化，高血压增加， 物理限制）。 这项研究的公共卫生相关性是为了更好地了解女性睡眠的变化， 从不同的种族和社会经济背景，并确定睡眠问题的危险因素。的 结果可以告知由于更年期相关睡眠而导致的不良健康结果的初级预防 干扰.

Sleep disruptions increase during mid-life in women, due in part to the effects of age itself, but also possibly due in part to the menopausal transition, i.e. changes in hormones, symptoms, and bleeding that occur during the menopausal transition. The current, revised proposal (Sleep II) will extend longitudinally the currently funded, multi-site, multi-ethnic cross-sectional study of sleep in midlife women (Sleep I). In Sleep I, leld-based examinations were conducted with 370 midlife pre-, peri- and postmenopausalCaucasian, African-American, and Chinese women from four of seven study sites from the Study of Women'sHealth Across the Nation (SWAN, a longitudinal study of menopause and aging), using in-home polysomnography, daily diaries and actigraphs, and self-report sleep questionnaires. In Sleep II, using a CoordinatedR01 mechanism, a second field-based examination will be conducted on the same sample of women (who will be aged 51-62 years), incorporating the same procedures. A widely-cited heuristic model of the pathophysiology of sleep disturbances will be applied to these longitudinal data to evaluate the development of menopause-related sleep disturbances in this multi-ethnic sample of women. This model attributes acute sleep disturbances to the combined effects of predisposing and precipitating factors, and persistenceof chronic sleep disturbances beyond the acute stressor to perpetuating factors. The specific aims for this longitudinal assessment of sleep through the menopausal transition are to identify potential: 1) predisposing factors (race, low socioeconomic status, low levels of physicalactivity, high body mass index, smoking, history of sleep problems, poor health status); 2) precipitating factors (vasomotor symptoms, new adverse life events, rapid increases in follicle stimulating hormone) for acute sleep disturbances during the transition; 3) perpetuating factors (poor sleep hygiene, dysfunctional attitudes and beliefs about sleep, heightened cognitive and physiologic arousal at night, race) for chronic sleep disturbances during the transition; and 4) adverse effects of sleep disturbances on subsequent health status during the early postmenopause (worsening metabolic profile and quality of life, increasedhypertension, physical limitations). The public health relevance of this research is to understand better the changes in the sleep ofwomen from different racial and socioeconomic backgrounds and identify risk factors for sleep problems. The results can inform primary prevention of adverse health outcomes due to the menopause-related sleep disturbances.