Reactivity and Regulation in the Intergenerational Transmission of PTSD

描述(由申请人提供)：项目摘要：这项指导临床科学家发展奖(K08)的目的是使候选人能够成为一名独立的调查员，对母亲创伤后应激障碍对父母养育、儿童反应和调节的影响，以及创伤应激的代际传播进行综合研究。该奖项的长期目标是为候选人提供信息并设计干预计划，以减轻母亲创伤后应激障碍对儿童的负面影响，并中断创伤后应激障碍的代际传播。为了实现这些目标，应聘者将完成一项职业发展计划，重点是提高管理和解释与反应和调节相关的多种心理生物功能措施的能力；创伤应激领域的方法，特别强调了解产妇创伤后应激障碍对儿童结局的影响和创伤后应激障碍代际传播所涉及的潜在机制；以及纵向数据收集和统计分析技术。培训将通过课程作业、教程和咨询专家以及具体的研究项目来完成。研究发展计划的重点是测试母亲创伤后应激障碍对育儿、儿童反应和自我调节发展的影响的具体模型，作为创伤应激代际传播的潜在中介。该研究计划包括两项研究：1)前瞻性检查母亲创伤后应激障碍、父母教养方式、婴儿第一年的反应和调节能力之间的关系；2)前瞻性分析创伤前调节能力在创伤暴露后创伤后创伤后应激障碍发展中的作用。通过该奖项获得的培训将使候选人准备提交R01申请，以进行一项关于母亲创伤后应激障碍对儿童结局的作用和潜在潜在影响机制的纵向研究。相关性：这项工作将有助于为减轻产妇创伤后应激障碍对儿童的负面影响的干预工作提供信息，防止创伤应激的代际传播，明确创伤后应激障碍病因学中风险和复原力的发展模式，并识别和治疗处于危险中的创伤儿童。这项工作还将对理解典型和非典型人群中跨多个系统的自我调节能力的发展以及对面临监管困难风险的人群进行干预具有更广泛的意义。

DESCRIPTION (provided by applicant): Project Summary: The purpose of this Mentored Clinical Scientist Development Award (K08) is to enable the candidate to become an independent investigator conducting integrative research on the impact of maternal PTSD on parenting, child reactivity and regulation, and the intergenerational transmission of traumatic stress. The long-term goal of this award is to prepare the candidate to inform and design intervention programs that mitigate the negative impact of maternal PTSD on children and interrupt the integenerational transmission of PTSD. To accomplish these goals, the candidate will complete a career development plan focused on promoting competence in the administration and interpretation of multiple measures of psychobiological functioning relevant to reactivity and regulation; methodology in the field of traumatic stress, with a particular emphasis on understanding the effects of maternal PTSD on child outcome and potential mechanisms involved in the intergenerational transmission of PTSD; and longitudinal data collection and statistical analysis techniques. Training will be accomplished via coursework, tutorials and consultation with experts, and specific research projects. The research development plan is focused on testing a specific model of the impact of maternal PTSD on parenting, child reactivity, and the development of self-regulation as potential mediators in the intergenerational transmission of traumatic stress. The research program consists of two studies: 1) a prospective examination of associations among maternal PTSD, parenting, and infant reactivity and regulatory abilities in the first year; and 2) a prospective analysis of the role of pre- trauma regulation abilities in the development of PTSD following trauma exposure. Training obtained via this award will prepare the candidate to submit an R01 application for a longitudinal study of the role of maternal PTSD on child outcome and potential underlying mechanisms of effects. Relevance: This work will help inform intervention efforts to mitigate the negative impact of maternal PTSD on children, prevent the intergenerational transmission of traumatic stress, specify developmental models of risk and resilience in the etiology of PTSD, and identify and treat at-risk traumatized children. This work will also have more general implications for understanding the development of self-regulatory abilities across multiple systems in typical and atypical populations and for intervening with populations at risk for regulatory difficulties.