ACISIR: Enhancing Recovery of People with Schizophrenia

描述（由申请人提供）：ACISIR的使命：促进精神分裂症患者的康复，旨在推进精神分裂症患者的治疗，以减少痛苦并改善功能结果，最终目标是促进康复。马里兰精神病学研究中心的基础临床研究专业知识将与服务研究部和精神分裂症行为治疗中心的服务和干预专业知识相结合，为社区环境中循证实践的发展、评估和实施提供信息。循证做法的发展将侧重于以下领域：1)治疗难治性阳性症状；2)持续阴性症状；3)认知障碍；4)同时发生的药物滥用；5)同时发生的疾病；6)加强恢复。社区实践的评估和循证实践的实施将集中在以下几个方面：1)药物治疗实践；2)健康和保健干预措施；3)社区使用权和职业提升计划；d)以消费者和家庭为中心的干预措施。ACISIR将通过以下方式支持这项工作：1)为调查人员提供评估、数据管理、统计和受试者招募基础设施支持；2)通过拟议的核心服务机构-实践研究网络开发和维护对各种临床站点的访问；3)开发和维护反映马里兰州全科实践的数据库，具有跨不同数据集交叉参考发现的能力；4)促进多学科研究和规划，以开发创新的新技术、方法和设计，以发展和实施循证实践；5)创新伦理方法；6)确保社区利益相关者在我们研究的各个方面做出贡献；7)为临床研究的学员提供培训。

DESCRIPTION (provided by applicant): The mission of our ACISIR: Enhancing Recovery of People with Schizophrenia, is to advance the treatment of people with schizophrenia in order to reduce suffering and to improve functional outcomes, with the ultimate goal of promoting the path to recovery. The basic clinical research expertise of the Maryland Psychiatric Research Center will be integrated with the services and intervention expertise of the Division of Services Research and the Center for Behavioral Treatment of Schizophrenia to inform the development, evaluation and implementation of evidence-based practices in community settings. The development of evidence-based practices will focus on the following areas: 1) treatment-resistant positive symptoms; 2) persistent negative symptoms; 3) cognitive impairments; 4) co-occurring substance abuse; 5) co-occurring medical conditions; and 6) enhancing recovery. The evaluation of community-based practices and implementation of evidence-based practices will focus on the following areas: 1) pharmacological treatment practices; 2) health and wellness interventions; 3) community tenure and occupational enhancement programs; and d) consumer and family centered interventions. The ACISIR will support this work by: 1) providing assessment, data management, statistical, and subject recruitment infrastructure support for investigators; 2) developing and maintaining access to a variety of clinical sites through the proposed Core Service Agency-Practice Research Network; 3) developing and maintaining databases reflecting general practice in Maryland, with the ability to cross-reference findings across different datasets; 4) fostering multi- disciplinary research and planning in order to develop innovative new technologies, methods, and designs for the development and implementation of evidence-based practices; 5) developing innovative ethics methods; 6) ensuring the contribution of community stakeholders in all aspects of our research; and 7) providing training for trainees in clinical research. Operations Core