Epidemiologic and Basic Science in Cancer Prevention

描述（由申请人提供）：我们在罗斯威尔公园癌症研究所（RPCI）的癌症预防愿景将转化研究的“从实验室到床边”范式扩展到“从实验室到人行道”模型，整合了基础实验室，流行病学和人口科学。我们坚持认为，预防需要基础科学的转化，就像癌症治疗一样。 这个R25 T计划的目标，基于癌症预防和人口科学在RPCI的部门，是教四个博士后研究员发展癌症预防研究的跨学科合作的能力基于“板凳到人行道”的模型。招聘将来自流行病学，人类学，生物化学，遗传学，分子生物学，医学，护理和病理学等领域。潜在的研究员将保持其核心学科的基础，同时超越这些学科，建立跨学科合作。这将通过制定专门课程、其他教学经验和深入研究来实现。为了鼓励这种学科的并列，学员将与一个主要的导师和一个或多个次要的导师在一个学科不同，但补充的主要导师和学员。一名学员将在01年被招募，为期三年的奖学金。该计划将在RPCI癌症预防和人口科学高级副总裁James马歇尔博士的领导下进行。 该计划建立在RPCI现有的优势之上：多学科合作的历史悠久;拥有众多资助研究项目的强大导师团队;以及与布法罗大学的合作关系。RPCI的高度跨学科的癌症预防计划由流行病学家，营养学家，基础科学家和医生组成，他们在计划内以及越来越多的计划间合作方面有着良好的记录。这个培训计划，从教师的坚定承诺，将提供来自不同科学学科的学员有机会利用在流行病学，遗传学，生物化学和细胞生物学，致癌，化学预防和临床科学的广泛的专业知识。我们将发展的合作模式是流行病学家/社会科学家PI马歇尔博士和生物化学家/分子生物学家联合PI Clement Ip博士之间的合作。

DESCRIPTION (provided by applicant): Our vision of cancer prevention at Roswell Park Cancer Institute (RPCI) extends the "bench to bedside" paradigm of translational research to a "bench to sidewalk" model integrating basic bench, epidemiologic and population sciences. We maintain that prevention demands the translation of basic science as much as cancer treatment does. The goal of this R25T program, based in the division of Cancer Prevention and Population Sciences at RPCI, is to teach four postdoctoral fellows to develop the ability for interdisciplinary collaboration in cancer prevention research based on the "bench to sidewalk" model. Recruitment will be from fields such as epidemiology, anthropology, biochemistry, genetics, molecular biology, medicine, nursing and pathology. Potential fellows will maintain grounding in their core disciplines while reaching beyond those disciplines to forge interdisciplinary collaborations. This will be achieved through the development of a specialized curriculum, other didactic experiences, and in-depth research. To encourage this juxtaposition of disciplines, trainees will work with a primary mentor and one or more secondary mentors in a discipline distinct from but complimentary to that of the primary mentor and trainee. One trainee will be recruited in Year 01 for a three year fellowship. The program will be under the leadership of James Marshall, PhD, the Senior Vice President for Cancer Prevention and Population Sciences at RPCI. This program builds on RPCI's existing strengths: an established history of multidisciplinary collaboration; a strong group of mentors with numerous funded research projects; and a collaborative relationship with the University at Buffalo. The highly interdisciplinary Cancer Prevention program at RPCI is comprised of a diverse group of epidemiologists, nutritionists, basic scientists, and physicians with a strong record of intra-programmatic, and increasingly inter-programmatic, collaboration. This training program, with strong commitment from the faculty, will provide trainees from disparate scientific disciplines the opportunity to take advantage of broad-based expertise in epidemiology, genetics, biochemistry and cell biology, carcinogenesis, chemoprevention, and clinical science. A model for the collaboration we will develop is that between the epidemiologist/social scientist PI, Dr. Marshall, and the biochemist/molecular biologist Co-PI, Dr. Clement Ip.