CORE--GENE ENVIRONMENT INTERACTION & DISEASE PREVENTION

描述（由申请人提供）：基因-环境相互作用和疾病预防研究核心利用环境健康科学和流行病学部门的多学科专业知识，开发，验证和使用分子生物标志物，以提供对暴露，剂量和易感性之间关系的更基本理解，并将这些工具应用于协作流行病学和干预研究。为了支持这一目标，研究核心有以下目标：1)为分子生物标志物的开发和验证提供重点。研究核心将实验室科学家和流行病学家聚集在一起，应用分析化学、分子生物学、生物化学、免疫学、毒理学、流行病学和生物统计学的方法来评估个体疾病风险。2)促进基础科学家和流行病学家之间的合作，优化分子生物标志物在基于人群的研究中的应用，以解决基因-环境相互作用在疾病病因学中的影响。反过来，这些人类研究的结果可以为中心研究人员提供见解和机会，以制定和评估疾病预防策略。3)开发先进的方法来评估过去和现在人群中接触有毒物质的情况。特别是，这个研究核心活跃于先进的统计方法应用于人类和实验生物标志物研究。4)与其他中心核心合作，发展与城市和州社区的联系，以研究导致该地区急性和慢性疾病的环境风险因素。5)继续发展生物标志物研究方面的培训项目，为我校各类博士生提供新的机会和职业发展道路。

Description (provided by applicant): The Research Core in Gene-Environment Interaction and Disease Prevention draws upon the multi-disciplinary expertise present in the Departments of Environmental Health Sciences and Epidemiology, to develop, validate and use molecular biomarkers to render a more basic understanding of between the relationship exposure, dose, and susceptibility, and to apply these tools to collaborative epidemiologic and intervention studies. The Research Core has the following goals, in support of this objective: 1) To provide a focus for the development and validation of molecular biomarkers. The Research Core brings together laboratory scientists and epidemiologists to apply methods of analytical chemistry, molecular biology, biochemistry, immunology, toxicology, epidemiology and biostatistics to roles the assessment of the individual risk of disease. 2) To facilitate collaborations between basic scientists and epidemiologists that optimize application of molecular biomarkers to population-based studies that address the impact of gene-environment interactions in the etiology of disease. In turn, findings from these human studies can provide insights and opportunities for Center investigators to develop and evaluate strategies for disease prevention. 3) To develop advanced methodologies for assessing past and current exposures to toxic agents in populations. In particular, this Research Core is active in the application of advanced statistical methods to human and experimental biomarker studies. 4) To develop ties to the communities of the city and state in collaboration with other Center Cores for the purposes of studying environmental risk factors contributing to acute and chronic diseases in the region. 5) To continue the development of training programs in biomarker research that will provide new opportunities and career paths for the diverse pre-and postdoctoral students at our institution.