CORE--MOLECULAR TOXICOLOGY

描述(申请人提供)：分子毒理学核心的总体目标是聚集一群精选的生物学家，他们的研究兴趣包括研究各种制剂造成的损害的基本毒性机制，包括金属、ROS、有机异物和DNA损伤剂。一个目标是集中他们不同的专长和兴趣的各个方面，以促进在研究方面的跨学科互动和合作，以解决与城市环境中的人类健康有关的重要问题。 另一个目标是让核心研究人员作为基础实验室科学和分子技术的资源，为所有中心研究核心的研究人员提供资源。分子毒理学核心的目标是通过以下活动促进的：首先，核心在学年期间每月举行研究会议，几个教员在会上讨论他们实验室目前的研究活动。每名研究人员有一个半小时的时间介绍最近的进展(许多未发表的作品)，并有充足的时间与其他研究人员进行公开讨论。会议不仅对主要研究人员开放，而且对研究核心3实验室的所有成员开放，包括工作人员和学生。除了研究会谈外，这些会议非常成功，还讨论了核心发展的想法/计划以及研究内部/研究间的核心合作、试点项目、共享资源的需求等。此外，在这些会议期间还提供了对核心设施所作补充的最新情况。例如，Guilarte博士最近概述了现有的成像设备。他的演讲引起了包括比斯瓦尔博士在内的研究核心3的几名研究人员的兴趣，这些信息对促进比斯瓦尔博士的研究计划的发展非常有帮助。第二，所有核心成员与其他中心成员和环境健康科学培训计划成员及其学生一起参加一年一度的科学研讨会。在这个背景下，一位特邀演讲者(S)主持了一个研讨会，随后是研究生和培训方案和中心教职员工的海报演示。第三，还通过共享使用核心设施来促进核心成员和中心成员之间的互动，在那里交流使用技术和实验方法的知识。第四，核心中心本身，并与其他中心研究核心一起，赞助霍普金斯大学教职员工和外部演讲者举办的中心范围内的研讨会。第五，中心所有成员都会收到年度进度报告的副本，这有助于让中心调查人员了解 每个研究和设施核心以及作为一个整体的中心的活动。

Description (provided by applicant): The overall objective of the Molecular Toxicology Core is to bring together a group of selected biologists whose research interests include studies on fundamental mechanisms of toxicity due to damage from a variety of agents including metals, ROS, organic xenobiotics and DNA damaging agents. A goal is to focus aspects of their diverse expertise and interests to foster interdisciplinary interactions and collaborations on research which addresses important problems relevant to human health in an urban environment. Another goal is to have Core Investigators serve as a resource of fundamental laboratory science and molecular technology to investigators in all Center Research Cores. The goals of the Molecular Toxicology Core are facilitated by the following activities: First, the Core holds monthly research meetings during the academic year where several faculty discuss the current research activities in their labs. Each investigator is provided with 1/2 hour to present recent advancements (much unpublished work) and is also provided ample time for open discussion with other investigators. The meetings are open to not only principal investigators, but also to all members of the Research Core 3 laboratories including staff and students. These meetings have been highly in successful in addition to research talks, ideas/plans for Core development and intra/inter-research Core collaborations, pilot projects, needs for shared resources, etc. are also discussed at these meetings. Moreover, recent updates on additions made to Core facilities are provided during these meetings. For example, Dr. Guilarte recently presented an overview of the imaging facilities that are available. His presentation sparked the interests of several investigators of Research Core 3, including Dr. Biswal and this information has been extremely helpful in fostering the development of Dr. Biswal's research program. Second, all Core Members along with other Center Members and members of the Environmental Health Sciences Training Program and their students participate in the annual Scientific Workshop. In this setting, an invited speaker(s) presents a seminar which is followed by poster presentations by graduate students and Training Program and Center faculty. Third, interaction among Core and Center Members is also facilitated through the shared use of Core facilities where knowledge of the use of techniques and experimental approaches is exchanged. Fourth, the Core itself, and in conjunction with other Center Research Cores, sponsors Center-wide seminars presented by Hopkins faculty and outside speakers. Fifth, all Center members receive copies of the annual progress reports and this serves to keep the Center investigators informed regarding the activities of each Research and Facility Core and the Center as a whole.