CORE GRANT FOR VISION RESEARCH

我们请求继续支持眼科的视觉研究中心， 1977年实施。这些资金将为我们中心的研究人员提供共享资源，这些资源对 继续现有的研究项目和有效地开发新项目。本中心 分为7个独立的资源/服务模块：机械车间;电子/计算机;研究 摄影/成像;组织学;组织培养;共用设备;和细胞成像。资金 其中四个单元的经费来自对我们的机构承诺， 研究中心除了通过提供共同的研究环境和生产力外， 集中服务，我们的中心鼓励和促进合作研究，并努力吸引到愿景 其他健康相关学科的研究科学家。我们的团队由8名独立调查员组成， 有NEI赠款，9名助理研究员和研究员。研究是在几个科学学科进行的 例如生物化学、药理学、生理学、细胞生物学和神经学。活跃的研究领域包括 青光眼;白内障;角膜疾病;房水动力学;角膜、透镜中的液体和电解质转运 和睫状体上皮;膜受体在眼内压调节中的作用;视网膜电图和 视觉诱发电位;眼神经系统的视觉控制;谷氨酸兴奋毒性机制 青光眼和神经保护方法;光学成像、电生理记录和计算机 模拟研究视觉系统的结构和动力学;以及 视网膜。该中心赠款的支持得到了该部坚定承诺的补充 和西奈山医疗中心在视觉研究方面取得了卓越的成就。7个项目中有4个需要NEI资金 模块。我们的视觉研究中心拥有超过15，000平方米的设施。英尺组织为 单独的实验室和模块运行的公共空间。

We request continuing support for a Vision Research Center in /me Department of Ophthalmology that was implemented in 1977. The funds will provide investigators in our Center shared resources that are vital for the continuation of current research programs and efficient development of new programs. Our Center is structured into 7 discrete resource/service modules: Machine Shop; Electronics/Computers; Research Photography/Imaging; Histology; Tissue Culture; Shared Equipment; and Cellular Imaging. Funds are requested for four of these modules with the remainder being funded through institutional commitment to our Research Center. In addition to enhancing the research environment and productivity by providing common centralized services, our Center stimulates and facilitates collaborative studies and strives to attract to vision research scientists in other health-related disciplines. Our group consists of 8 independent investigators who have NEI grants, 9 associate investigators and fellows. Research is conducted in several scientific disciplines such as biochemistry, pharmacology, physiology, cell biology, and neurology. Areas of active research include glaucoma; cataracts; corneal diseases; aqueous humor dynamics; fluid and electrolyte transport in cornea, lens and ciliary epithelium; role of membrane receptors in regulation of intraocular pressure; electroretinogram and visual-evoked potentials; visual control of the oculomotor system; mechanisms of glutamate excitotoxicity in glaucoma and methods of neuroprotection; optical imaging, electrophysiological recordings and computer simulations to study the architecture and dynamics of the visual system; and degenerative diseases of the retina. The support of the CORE Center grant is complemented by a strong commitment of the Department and the Mount Sinai Medical Center to excellence in vision research. NEI funds are requested for 4 of the 7 modules. Our Vision Research Center has facilities with an area of more than 15,000 sq. ft. organized as individual laboratories and common space where modules operate.