New Directions in Biology and Disease of Skeletal Muscle

描述（由申请人提供）：本提案寻求对将于2008年4月27日至4月30日在路易斯安那州新奥尔良温德姆酒店举行的“骨骼肌生物学和疾病新方向”国际研讨会的部分支持。这是该系列举行的第三次会议。包括肌营养不良和肌病在内的肌肉退行性疾病由大量不同基因中的个体基因缺陷引起。在许多情况下，这些基因可以聚集成功能组，突出肌肉正常和异常功能的关键途径。这个“新方向”系列的第一次会议由临床医生和科学家参加，涵盖了发病机制和治疗导向的研究。从这次会议上发展了许多合作，重要的是，这次会议建立了指导临床试验设计的基础。第二次“新方向”会议于2006年在德克萨斯州的达拉斯举行。这次会议出席人数众多，并强调了可以转化为临床治疗和临床前测试的关键发现。我们现在已经计划了2008年新奥尔良“新方向”会议的第三部分。本次会议与其他会议不同，将介绍正在进行的临床试验的数据。此外，我们将重点关注其他形式的肌肉疾病的目标识别，这些疾病可能无法用目前的方法治疗。讨论的主题包括核膜生物学、肌肉系统生物学、模型和治疗、肌肉疾病中的RNA重复和收缩、基质和干细胞以及肌营养不良蛋白复合体。与其他会议一样，这次会议为期三天，将有大约42场发言。将包括两个海报会议。大约25%的演讲者将根据提交的摘要命名，以纳入与肌肉退行性疾病领域相关的最及时和最前沿的发现。公共卫生相关性：该提案寻求对将于2008年4月27日至4月30日在新奥尔良温德姆酒店举行的“骨骼肌生物学和疾病新方向”国际研讨会的部分支持。这次会议是非常独特的，其重点是肌肉疾病和治疗。会议汇集了研究人员和临床医生，以确定新的治疗目标，以治疗肌肉退行性疾病，包括肌肉萎缩症和肌病。

DESCRIPTION (provided by applicant): This proposal seeks partial support for an international symposium on "New Directions in Biology and Disease of Skeletal Muscle," to be held April 27 to April 30, 2008 at the New Orleans Wyndham Hotel in New Orleans, LA. This is the third meeting held in this series. Muscle degenerative diseases including the muscular dystrophies and myopathies arise from individual gene defects in a large number of distinct genes. In many cases, these genes can be clustered into functional groups that highlight critical pathways for normal and abnormal function of muscle. The first meeting in this "New Directions" series was attended by clinicians and scientists and covered pathogenesis and treatment-oriented research. A number of collaborations developed from this meeting, and importantly, this meeting established groundwork that has directed clinical trial design. The second "New Directions" meeting was held in 2006 in Dallas, TX. This meeting was well attended and emphasized key findings that could be translated into clinical therapeutics as well as preclinical testing. We have now planned the third installment of the "New Directions" meeting for New Orleans in 2008. This meeting is evolving from the others in that data from ongoing clinical trials will be presented. Additionally, we will focus on target identification for other forms of muscle disease that may not be treated with current approaches. Topics to be discussed include nuclear membrane biology, muscle systems biology, models and therapy, RNA repeats and contractions in muscle disease, matrix and stem cells and the dystrophin complex. The meeting will be held, as the others, over three days with approximately 42 presentations. Two poster sessions will be included. Approximately 25% of the speakers will be named based on submitted abstracts to allow the inclusion of the most timely and cutting edge findings relevant to the field of the muscle degenerative diseases. PUBLIC HEALTH RELEVANCE: This proposal seeks partial support for an international symposium on "New Directions in Biology and Disease of Skeletal Muscle," to be held April 27 to April 30, 2008 at the New Orleans Wyndham Hotel in New Orleans, LA. This meeting is highly unique in its focus on muscle diseases and therapy. The meeting brings together researchers and clinicians to identify new targets for therapy to treat the muscle degenerative diseases including the muscular dystrophies and myopathies.