2008 Thiol-based Redox Regulation and Signaling Gordon Research Conference

描述（由申请人提供）： 该提案要求支持将于2008年5月25日至30日在意大利的Il Ciocco举行的基于硫醇的氧化还原调节和信号传导的戈登研究会议。氧化还原生物学领域是生物医学科学的关键，因为越来越多的细胞功能和损伤被发现与氧化还原过程有关。 氧化还原控制的核心是利用硫醇进行氧化还原交易的系统。 含巯基蛋白质是细胞中的主要抗氧化剂，并且各种磷酸酶、激酶和转录因子中的巯基的可逆氧化将基于巯基的氧化还原化学与基于磷酸化的信号传导、凋亡和基因调控联系起来。 硫醇基氧化还原稳态的失调对心血管疾病、癌症和其他复杂疾病的进展具有重要意义，并且是衰老过程的重要组成部分。 本次会议是继2006年在美国举行的非常成功的首次会议之后的第二个周期。本次会议的主席和副主席分别是一名基础科学家和一名医生科学家，代表生物学家、化学家和临床医生，从事该领域的各个方面的工作。这次会议为自由交流思想和方法提供了一个场所（后者往往限制了这一特定领域的进展）。虽然会议的主题领域基础广泛，但其与心血管疾病的相关性在方案上得到了很好的体现。通过将具有生物物理方法，生物信息学和动物模型系统等各种专业知识的研究人员与医生相结合，预计会议将进一步促进合作并促进科学进步。(End摘要）

DESCRIPTION (provided by applicant): This proposal requests support for a Gordon Research conference on Thiol-based Redox Regulation and Signaling to be held between May 25-30, 2008 at Il Ciocco in Italy. The field of redox biology is key to the biomedical sciences as an increasing number of cellular functions and impairments are found linked to redox processes. Central to redox control are systems that utilize thiols to perform redox transactions. Thiol-containing proteins are major antioxidants in cells and reversible oxidation of thiols in various phosphatases, kinases and transcription factors links thiol-based redox chemistry to phosphorylation-based signaling, apoptosis and gene regulation. Dysregulation of thiol-based redox homeostasis has major implications for the progression of cardiovascular diseases, cancer and other complex diseases and is a significant component of the process of aging. This conference is in its second cycle after a very successful inaugural meeting in the U.S. in 2006. The chair and vice-Chair for this meeting are a basic and a physician scientist respectively and representative of the biologists, chemists and clinicians, working on varied aspects of the field. This conference provides a venue for the free exchange of ideas and methodologies (the latter often limits progress in this particular field). While the thematic area of the conference is broad-based, its relevance to cardiovascular diseases is well represented programmatically. By combining investigators with varied expertise for e.g. in biophysical methods, bioinformatics and animal model systems, with physicians, the meeting is expected to further stimulate collaborations and catalyze scientific progress. (End of Abstract)