Plasminogen Activation & Extracellular Proteolysis Gordon Research Conference

描述(由申请人提供)： 本申请寻求对将于2008年2月10日至15日在加利福尼亚州文图拉举行的关于纤溶酶原激活和胞外蛋白分解的戈登研究会议的部分支持。戈登会议系列成立于1990年，现在每两年举行一次。2004年和2006年的会议非常成功，预计2008年会议将延续这一传统。蛋白水解酶的调节和纤溶酶原的激活是科学研究、临床医学和生物技术领域中迅速发展的领域。这些领域对于血液疾病的新疗法的开发具有独特的重要性，先前的发现导致了用于心脏病发作和血栓性中风的纤溶酶原激活剂(TPA)的开发。纤溶酶原激活和细胞外蛋白分解戈登会议将提供一个独特的机会，将来自世界各地的科学家聚集在一起，解决心血管疾病和其他疾病的病因、预防和治疗方面的当前问题，目标是将发现转化为新的创新疗法。重点将放在发展、组织修复、动脉粥样硬化、再狭窄、血管生成、肿瘤进展、血栓溶解、神经功能、阿尔茨海默病和中风中纤维蛋白溶解系统和其他蛋白质分解系统之间的新出现的关系。重点将放在提供与止血相关的蛋白酶、蛋白酶受体和抑制物在疾病中的作用和相互作用的机械性见解的方法上。与会者将从网上提交的申请中挑选，我们将积极寻找妇女和代表性不足的少数群体作为发言者、会议主席、海报和摘要演讲者以及与会者，以寻求均衡的代表性。在2008年会议上，关于纤溶酶原激活和胞外蛋白分解的戈登-凯南研究研讨会(GRS)将于2月9-10日，即会议开始之前第一次举行。通过这一创新的研讨会计划，纤溶酶原激活和细胞外蛋白分解领域的研究生和博士后研究员将有机会讨论他们目前的研究，同时与他们的同行建立网络，预计将导致未来的合作、科学成就和职业发展。GRS计划将由研究生和博士后在顶尖资深科学家的支持下组织。关于纤溶酶原激活和胞外蛋白分解的戈登会议传统上是一次非常成功和令人愉快的会议，我们相信目前的计划有潜力继续这一传统。(摘要结束)

DESCRIPTION (provided by applicant): This application seeks partial support for the Gordon Research Conference on Plasminogen Activation and Extracellular Proteolysis, to be held February 10-15, 2008, in Ventura, California. This Gordon Conference series was founded in 1990 and is now held biennially. The 2004 and 2006 meetings were highly successful and it is anticipated that the 2008 meeting will continue this tradition. Proteolytic regulation and plasminogen activation are rapidly evolving fields at the interface of scientific research, clinical medicine, and biotechnology. These fields are uniquely important for the development of new therapies for blood disorders, and prior discoveries led to the development of plasminogen activator (tPA) for heart attacks and thrombotic stroke. The Plasminogen Activation and Extracellular Proteolysis Gordon Conference will provide a unique opportunity to bring together scientists from around the world to address current issues in the causes, prevention and treatment of cardiovascular diseases and other disorders, with the goal of translating findings to new innovative therapies. Emphasis will be placed on emerging relationships between the fibrinolytic system and other proteolytic systems in development, tissue repair, atherosclerosis, restenosis, angiogenesis, tumor progression, thrombolysis, neuronal function, Alzheimer's disease and stroke. Special emphasis will be placed on approaches that provide mechanistic insights into the role and interplay of hemostasisrelated proteases, protease receptors, and inhibitors in disease. Participants will be selected from applications submitted on-line and we will seek a balanced representation by actively seeking women and under-represented minorities as speakers, session chairs, poster and abstract presenters, and attendees. For the first time at the 2008 conference, a Gordon-Kenan Research Seminar (GRS) on Plasminogen Activation and Extracellular Proteolysis will take place on February 9-10, immediately prior to the start of the conference. Through this innovative seminar program, graduate students and postdoctoral fellows in the fields of plasminogen activation and extracellular proteolysis will have an opportunity to discuss their current research while building networks with their peers that are anticipated to lead to future collaboration, scientific achievement and career development. The GRS program will be organized by graduate students and postdocs with support from leading senior scientists. The Gordon Conference on Plasminogen Activation and Extracellular Proteolysis has been traditionally a highly successful and enjoyable meeting and we believe that the current program has the potential to continue this tradition. (End of Abstract)