Training Grant in Cancer Biology

描述(由申请人提供)：本申请寻求资助一个新的综合癌症生物学(ICB)项目，以培养致力于癌症研究事业的博士后和博士后实习生。该项目将设在马里兰大学格林鲍姆(UMG)癌症中心，包括来自马里兰大学巴尔的摩校区多个基础科学和临床系的教师。参与的学院是根据他们在癌症研究方面的科学成就和资助记录、对转化性癌症研究的兴趣以及指导学员的经验来挑选的。这一多学科项目的一个主要目标是为学员提供一个令人兴奋和鼓舞人心的学术环境，在其中进行跨学科的癌症研究，利用尖端技术做出深刻的发现，从而产生下一代敏感的诊断学和特定的治疗学。受训人员能够欣赏转化性癌症研究，并能够与指导他们职业生涯的科学家和临床医生互动团队进行有效互动。两个关键的发展证实了马里兰大学对癌症研究的承诺，并证明了我们对培训计划的要求是合理的。首先是成立了UMG癌症中心，其使命是整合创新的基础、转化和临床研究，以影响对癌症的理解、诊断、治疗和预防，并为癌症患者提供最先进的临床护理。UMG癌症中心于2008年作为国家癌症研究所(NCI)指定的癌症中心获得资助，以表彰其卓越的科学水平和出色的患者护理。第二，在生命科学研究生计划的分子医学计划内，成立了一个新的跨部门癌症生物学研究生计划。ICB培训计划建立在癌症生物学研究生计划的基础上，并与UMG癌症中心的计划相结合。它的范围是高度跨学科的，使学生能够在基础、翻译和临床癌症研究的许多不同方面获得坚实的基础，同时允许他们灵活地专注于他们感兴趣的领域。ICB培训计划的一个真正优势是拥有几乎所有当代生物医学科学专业知识的庞大、多样化的癌症教员群体指导受训人员的能力。我们的博士后和博士后实习生有机会在互动的多学科环境中使用最先进的方法研究癌症的分子基础，并与临床研究相结合--这是ICB培训计划的独特资产。

DESCRIPTION (provided by applicant): This application seeks funding of a new program in Integrative Cancer Biology (ICB) to train post-doctoral and pre-doctoral trainees committed to careers in cancer research. The program will be based in the University of Maryland Greenebaum (UMG) Cancer Center, and includes faculty from multiple basic science and clinical departments on the University of Maryland Baltimore campus. Participating Faculty have been selected based on their scientific achievements and track record of funding in cancer research, interest in translational cancer research and experience in mentoring trainees. A major goal of this multi-disciplinary program is to provide trainees with an exciting and stimulating academic environment in which to pursue interdisciplinary cancer research, utilizing cutting edge technologies to make profound discoveries that will lead to the next generation of sensitive diagnostics and specific therapeutics. Trainees are provided with an appreciation for translational cancer research and with the ability to interact effectively with interactive teams of scientists and clinicians that will guide their careers. Two key developments substantiate the commitment of the University of Maryland to cancer research and justify our request for a training program. The first was the establishment of the UMG Cancer Center, whose mission is to integrate innovative basic, translational and clinical research to impact the understanding, diagnosis, treatment and prevention of cancer, and to provide state-of-the-art clinical care for cancer patients. The UMG Cancer Center was funded as a National Cancer Institute (NCI)-designated cancer center in 2008 in recognition of its scientific excellence and outstanding patient care. Second, a new inter-departmental graduate program in Cancer Biology was formed within the Molecular Medicine Program of the Graduate Program of Life Sciences. The ICB training program builds on the Cancer Biology graduate program and is integrated with the programs of the UMG Cancer Center. It is highly "interdisciplinary" in scope and enables students to obtain a solid grounding in many different aspects of basic, translational and clinical cancer research, yet allows them the flexibility to specialize in their area of interest. A real strength of the ICB training program is the capacity of the large, diverse group of cancer faculty with expertise in virtually all contemporary biomedical science to mentor trainees. Our pre-doctoral and post-doctoral trainees have the opportunity to investigate the molecular basis of cancer using state-of-the-art methodologies in an interactive, multidisciplinary environment, and in conjunction with clinical research--distinctive assets of the ICB Training program.