Collaborative Development Fund

合作与发展基金 HARC中心的一个重要部分将是招募广泛的合作者，以帮助进一步 鉴定和验证艾滋病毒-宿主蛋白复合体，促进复合体的结构确定，利用 结构信息，以更深入地探讨HIV调节和辅助的生物学功能 蛋白质，并扩展高通量表达、结构测定、MS等方面的技术发展 方法：冷冻-电子显微镜和断层扫描。我们将通过以下方式促进这些重要的合作：积极接触 通过直接联系向相关研究人员；组织合作者和可能的合作者的访问 向HARC中心计划未来的研究方向；为有希望的合作提供种子资金； 促进合作者的筹资机会，包括以下机构宣布的相关R21/R33机制 NIAID；广泛传播HARC中心的目标、结果和可用资源，以鼓励 进一步的外部参与；以及积极参加国家和国际会议。我们有 要求将直接成本预算的5%用于协作发展基金，以支持这些活动。 鉴于HARC中心最初成立时所涵盖的项目范围广泛，我们有 征求直接研究辅助蛋白和调节蛋白的潜在合作者的信件 构成本项目重点的技术。随着HARC中心变得更加成熟，新的 研究方向将由HARC中心执行委员会和内部和 外部咨询委员会，并酌情改变指导方针和分配资金。我们最初的 协作努力在第四节中有更详细的描述。

COLLABORATIONS AND DEVELOPMENT FUND An essential part of the HARC Center will be to enlist a wide range of collaborators to help further identify and validate HIV-host protein complexes, facilitate structure determination of the complexes, utilize structural information to more deeply probe the biological functions of the HIV regulatory and accessory proteins, and extend technological developments in high-throughput expression, structure determination, MS methods, cryo-EM, and tomography. We will facilitate these essential collaborations by: actively reaching out to relevant researchers through direct contacts; organizing visits of collaborators and possible collaborators to the HARC Center to plan future research directions; providing seed funding for promising collaborations; facilitating funding opportunities for collaborators, including the related R21/R33 mechanism announced by NIAID; widely disseminating the goals, results, and available resources of the HARC Center to encourage further outside participation; and actively participating in national and international meetings. We have requested 5% of the direct cost budget for a Collaboration Development Fund to support these activities. Given the breadth of projects encompassed in the initial establishment of the HARC Center, we have solicited letters from potential collaborators working directly on the accessory and regulatory proteins and technologies that comprise the focus of this project. As the HARC Center becomes more established, new research directions will be evaluated thoroughly by the HARC Center Executive Council and internal and external advisory committees, and directions altered and funds allocated as appropriate. Our initial collaborative efforts are described in more detail in Section IV.