Core B

核心B.交互验证核心(IVC) 导演：克里斯·艾肯博士 上述针对核心A的生物信息学分析将极大地细化候选交互作用列表 HIV-1蛋白和细胞靶标之间的关系，这与目前公共数据库中提供的结果不同。然而， 结构分析目标的选择应基于已证明的 HIV-1致病机制的相互作用。IVC将在PCHPI中发挥两个关键作用。首先，独立投资委员会将通知 通过识别那些在HIV感染中表现出功能后果的基因来选择结构分析的目标 细胞。其次，IVC将测试由以下结构性数据产生的特定假设 PCHPI和可能由该计划资助的其他中心。因此，独立投资委员会将服务于整合 PCHPI在整个进程的早期和后期都发挥了关键作用。

Core B. Interactions Validation Core (IVC) Director: Chris Aiken, PhD The bioinformatics analyses described above for Core A will greatly refine the list of candidate interactions between HIV-1 proteins and cellular targets from that currently available in the public databases. However, the choice of targets for structural analysis should be based on demonstrated functional relevance of the interactions for HIV-1 pathogenesis. The IVC will play two key roles in the PCHPI. First, the IVC will inform the choice of targets for structural analysis by identifying those that exhibit functional consequences in HIVinfected cells. Second, the IVC will test specific hypotheses generated by the structural data that emerge from the PCHPI and potentially other Centers funded by the program. Thus, the IVC will serve to integrate the PCHPI by playing key roles at both early and late stages of the overall process.